Evidence map›Paper›PMID 30139360›Full record

SynthesisRadiation oncology (London, England)2018

The effects of prophylactic cranial irradiation versus control on survival of patients with extensive-stage small-cell lung cancer: a meta-analysis of 14 trials.

Wei Ge, Huilin Xu, Yafei Yan, Dedong Cao

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Radiation oncology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04947774 (Real-world Study of Prophylactic Cranial Irradiation After Immunotherapy Combined With Chemotherapy for Extensive-stage Small Cell Lung Cancer), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04947774 unknown statusnot on this mapstarted 2020, after this paper: background citation

Real-world Study of Prophylactic Cranial Irradiation After Immunotherapy Combined With Chemotherapy for Extensive-stage Small Cell Lung Cancer

TypeobservationalSponsorChinese Academy of Medical SciencesRan2020 to 2022Enrolled100ConditionsExtensive-stage Small-cell Lung CancerArmsProphylactic Cranial Irradiation
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Article
  4. Review
  5. New perspectives in the management of small cell lung cancer.World journal of clinical oncology · 2022
    Review
  6. Review
  7. GOECP/SEOR radiotherapy guidelines for small-cell lung cancer.World journal of clinical oncology · 2021
    Review
  8. Current and future strategies in radiotherapy for small-cell lung cancer.Journal of clinical and translational research · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wei GeDepartment of Oncology, RenMin Hospital of WuHan University, WuHan, 430000, Hubei, China.
Huilin XuDepartment of Oncology, The Fifth Hospital of WuHan, WuHan, 430000, Hubei, China.
Yafei YanDepartment of Oncology, RenMin Hospital of WuHan University, WuHan, 430000, Hubei, China.
Dedong CaoDepartment of Oncology, RenMin Hospital of WuHan University, WuHan, 430000, Hubei, China. caodedong123@whu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA recent Japanese study suggested prophylactic cranial irradiation (PCI) failed to improve survival of extensive-stage small-cell lung cancer (SCLC). However, previous studies showed that PCI was beneficial in reducing the rate of mortality for extensive-stage SCLC. In this study, we aimed to evaluate the impact of PCI on the survival of patients diagnosed with extensive-stage SCLC by meta-analysis.

methodsPubMed, Embase, the Cochrane library and Chinese Biomedical Literature database (CBM) were systematically searched to identify eligible clinical studies assessing the efficacy of PCI in extensive-stage SCLC patients. After extracting survival data, brain metastasis, and response rates, the pooled estimates were calculated.

resultsA total of 14 clinical studies were included, involving 1221 cases in the PCI group and 5074 in the control group. The results showed that PCI significantly improved overall survival (Hazard ratio (HR) = 0.57; 95% confidence interval (CI): 0.47, 0.69; p < 0.001) and brain metastasis (risk ratio (RR) =0.47, 95%CI: 0.33, 0.69; p < 0.01). Subgroup analysis along with sensitivity analysis suggested that PCI effects on overall survival were independent of region, pre-PCI brain metastasis status and PCI administration timing.

conclusionPCI improves overall survival in extensive-stage SCLC. More randomized controlled trials are needed to verify our findings.

Indexed as

Brain NeoplasmsCranial IrradiationFemaleHumansLung NeoplasmsMaleSensitivity and SpecificitySmall Cell Lung CarcinomaBrain metastasisEvidence-based medicineMeta-analysisProphylactic cranial irradiationSmall-cell lung cancerSurvival

Identifiers

PMID30139360
PMCPMC6107943

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.