ArticleKorean journal of anesthesiology2018
Designing the ideal perioperative pain management plan starts with multimodal analgesia.
Article in Korean journal of anesthesiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 5 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- Esmolol as an Adjunct in Multimodal Anesthesia: A Systematic Review and Meta-Analysis of Its Opioid-Sparing and Analgesic Effects.Anesthesia and analgesia · 2026Pooled it
- Preoperative Nonopioid Analgesia Reduces Postoperative Opioid Consumption After Arthroscopic Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials.The American journal of sports medicine · 2026Pooled it
- Comparative Efficacy of Nerve Blocks for Post-Operative Analgesia Following Robot-Assisted Prostatectomy: A Systematic Review.Current pain and headache reports · 2025Pooled it
- Comparison of efficacy and safety profiles of perioperative sufentanil and remifentanil: a systematic review and meta-analysis with trial sequential analysis.Systematic reviews · 2025Pooled it
- Pooled it
- Multimodal Conscious Analgesia with Oliceridine and Alfentanil Plus Local Anesthesia in Revisional Upper Eyelid Blepharoplasty: A Multicenter Randomized Clinical Trial.Aesthetic plastic surgery · 2026Trial
- Analgesic efficacy of ilioinguinal/iliohypogastric, transversus abdominis plane, and quadratus lumborum blocks in inguinal hernia surgery: A prospective randomized controlled trial.The Journal of international medical research · 2026Trial
- A Randomized Controlled Trial of Intraoperative Ketamine for Acute Postsurgical Pain after Breast Cancer Surgery: The Moderating Effect of Baseline Temporal Summation of Pain.Anesthesiology · 2025Trial
- Comparison of Bilateral Rectus Sheath Block and Thoracic Epidural Analgesia for Postoperative Pain Control After Open Gastrectomy: A Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2025Trial
- Effect of bilateral ultrasound-guided erector spinae plane block on postoperative pain after open lumbar spinal surgery: a double-blind, randomized controlled trial.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Trial
- Comparison of the Analgesic Efficacy of Opioid-Sparing Multimodal Analgesia and Morphine-Based Patient-Controlled Analgesia in Minimally Invasive Surgery for Colorectal Cancer.World journal of surgery · 2022Trial
- Postoperative Effects of Celecoxib on Opioid Use and Pain Control After Benign Oropharyngeal Surgery.The Laryngoscope · 2026Article
- An update on the role of multimodal analgesia in perioperative pain management.Korean journal of anesthesiology · 2026Review
- Impact of multimodal analgesia using intravenous non-opioid agents on immediate postoperative rescue analgesic use following minor general surgery: a retrospective study.The Korean journal of pain · 2026Article
- Safety of additional intravenous acetaminophen/ibuprofen administration in patients undergoing robot-assisted renal surgery with postoperative ketorolac-based patient-controlled analgesia: A retrospective propensity-score-matched analysis.Investigative and clinical urology · 2026Article
- Feasibility evaluation of large language models in anesthesia-specific post-operative care instructions for total knee arthroplasty.PEC innovation · 2026Article
- Venlafaxine as Monotherapy and in Combination Regimens in Acute Rodent Nociception Experimental Models: A Review.International journal of molecular sciences · 2026Review
- Comparative efficacy of different nerve block technologies for postoperative pain management in hip arthroplasty: a network meta-analysis.European journal of medical research · 2026Article
- Prevention and Treatment of Postsurgical Pain: Pharmacologic and Nonpharmacologic Interventions Across the Surgical Continuum.Clinics in geriatric medicine · 2026Review
- Hydrogels and Organogels for Local Anesthetic Delivery: Advances, Challenges, and Translational Perspectives.Gels (Basel, Switzerland) · 2025Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multimodal analgesia is defined as the use of more than one pharmacological class of analgesic medication targeting different receptors along the pain pathway with the goal of improving analgesia while reducing individual class-related side effects. Evidence today supports the routine use of multimodal analgesia in the perioperative period to eliminate the over-reliance on opioids for pain control and to reduce opioid-related adverse events. A multimodal analgesic protocol should be surgery-specific, functioning more like a checklist than a recipe, with options to tailor to the individual patient. Elements of this protocol may include opioids, non-opioid systemic analgesics like acetaminophen, non-steroidal anti-inflammatory drugs, gabapentinoids, ketamine, and local anesthetics administered by infiltration, regional block, or the intravenous route. While implementation of multimodal analgesic protocols perioperatively is recommended as an intervention to decrease the prevalence of long-term opioid use following surgery, the concurrent crisis of drug shortages presents an additional challenge. Anesthesiologists and acute pain medicine specialists will need to advocate locally and nationally to ensure a steady supply of analgesic medications and in-class alternatives for their patients' perioperative pain management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.