Evidence map›Paper›PMID 30138538›Full record

Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2019

27-Hydroxycholesterol, an Endogenous SERM, and Risk of Fracture in Postmenopausal Women: A Nested Case-Cohort Study in the Women's Health Initiative.

Po-Yin Chang, David Feldman, Marcia L Stefanick, Donald P McDonnell, Bonne M Thompson, Jeffrey G McDonald, Jennifer S Lee

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Plasma oxysterols are associated with serum lipids and dementia risk in older women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Po-Yin ChangSchool of Medicine, Stanford University, Stanford, CA, USA.
David FeldmanSchool of Medicine, Stanford University, Stanford, CA, USA.
Marcia L StefanickSchool of Medicine, Stanford University, Stanford, CA, USA.
Donald P McDonnellSchool of Medicine, Duke University, Durham, NC, USA.
Bonne M ThompsonCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jeffrey G McDonaldCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jennifer S LeeSchool of Medicine, Stanford University, Stanford, CA, USA.

Funding

TRANSCRIPTIONAL REGULATION OF LDL RECEPTOR PROMOTERP01HL020948 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GOLDSTEIN, JOSEPH L · 1985 to 2021
$103.1M
Diabetes, Endocrinology and Metabolism Training GrantT32DK007217 · NIDDK · STANFORD UNIVERSITY · PI Justin Pierce Annes, David Matthew Maahs · 1987 to 2026
$7.2M
Mechanism of Action of Estrogens and AntiestrogensR37DK048807 · NIDDK · DUKE UNIVERSITY · PI MCDONNELL, DONALD P · 2005 to 2014
$5.0M
MECHANISM OF ESTROGENS AND ANTIESTROGENSR01DK048807 · NIDDK · DUKE UNIVERSITY · PI MCDONNELL, DONALD P · 1995 to 2019
$4.3M
NHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS P01 HL020948NIDDK NIH HHS R01 DK048807NIDDK NIH HHS R37 DK048807NIDDK NIH HHS T32 DK007217
6 · The paper itself

Abstract

27-Hydroxycholesterol (27HC) is a purported, novel endogenous SERM. In animal models, 27HC has an anti-estrogen effect in bone, and 17β-estradiol mitigates this effect. 27HC in relation to fracture risk has not been investigated in humans. Depending on the level of bioavailable 17β-estradiol (bioE

Indexed as

AgedCase-Control StudiesEstrogens, Conjugated (USP)FemaleFollow-Up StudiesHip FracturesHumansHydroxycholesterolsMiddle AgedPostmenopauseProgestinsProspective StudiesRisk FactorsSelective Estrogen Receptor ModulatorsSpinal Fractures27-hydroxycholesterolEstrogens, Conjugated (USP)HydroxycholesterolsProgestinsSelective Estrogen Receptor Modulators27-HYDROXYCHOLESTEROLESTRADIOLFRACTUREOXYSTEROLPOSTMENOPAUSAL WOMEN

Identifiers

PMID30138538
PMCPMC6478389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.