ArticlePloS one2018
Spleen size evaluation in children: Time to define splenomegaly for pediatric surgeons and pediatricians.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Imaging assessment and interventional management of paediatric portal hypertension: an update.Pediatric radiology · 2026Review
- Behind the splenomegaly: a parasitic twist in siblings with beta thalassemia trait.BMC pediatrics · 2026Article
- A Study of the Clinico-Etiological Profile of Splenomegaly Among Children in a Tertiary Care Hospital.Cureus · 2025Article
- The Basel ultrasonography protocol for assessing hepatosplenic pathologies in Asian schistosomiasis: report of a WHO expert meeting.Infectious diseases of poverty · 2025Article
- Study of Adult and Pediatric Spanish Patients with Cryptogenic Splenomegaly and Splenectomy.Diseases (Basel, Switzerland) · 2025Article
- Ultrasonographic assessment of spleen size and pattern of change among sickle cell disease patients and healthy controls in North-Eastern Nigeria.Ultrasound (Leeds, England) · 2024Article
- Clinical and laboratory factors associated with splenic dysfunction among patients with sickle cell disease in a malaria endemic region.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2023Article
- More precise measurement of irregular splenic volume in cirrhotic patients with portal hypertension.iLIVER · 2023Article
- Sonographic Evaluation of the Morphology of Kidneys Among Apparently Healthy Children in Northwest Ethiopia, 2021: The Normal Limits and Percentile Curves.Canadian journal of kidney health and disease · 2023Article
- Spleen size in homozygous sickle cell disease: trends in a birth cohort using ultrasound.The British journal of radiology · 2022Article
- Immunological imbalance in microcephalic children with congenital Zika virus syndrome.Medical microbiology and immunology · 2022Article
- Reference Ranges of Age-Based Liver, Spleen, Pancreas, and Kidney Size in Conjunction with Waist Circumference in Children.Turkish archives of pediatrics · 2022Article
- The AlexisUpdates in surgery · 2021Article
- Sonographic evaluation of spleen size in apparently healthy children in north-west Ethiopia, 2020: time to define splenomegaly.BMC pediatrics · 2021Article
- Prospective study of the natural history of chronic acid sphingomyelinase deficiency in children and adults: eleven years of observation.Orphanet journal of rare diseases · 2021Article
- Splenomegaly in Children and Adolescents.Frontiers in pediatrics · 2021Review
- High Resolution Manometry Guidance During Laparoscopic Fundoplication in Pediatric Surgically "Fragile" Patients: Preliminary Report.Children (Basel, Switzerland) · 2020Article
- Occurrence of Portal Hypertension and Its Clinical Course in Patients With Molecularly Confirmed Autosomal Recessive Polycystic Kidney Disease (ARPKD).Frontiers in pediatrics · 2020Article
- Ultrasonography of the pediatric spleen: a pictorial essay.Journal of ultrasound · 2019Review
- Differential hepatic features presenting in Wilson disease-associated cirrhosis and hepatitis B-associated cirrhosis.World journal of gastroenterology · 2019Observational
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe determined the range of normal spleen dimensions evaluated by ultrasonography (US) in children according to sex and age and the relationship between splenic measurements, auxological data and body proportions, in order to define splenomegaly parameters in support of the surgical mini-invasive approaches in pediatrics.
methodsWe prospectively examined 317 caucasian children of both sexes. The patients were divided into three groups: 0-3 years; 4-10 years; 11-18 years. Sex, weight, height/length, body mass index (BMI), waist circumference and xipho-pubic distance were determined for each child. US spleen evaluation included longitudinal/antero-posterior/transverse diameters, transverse area and volume. Spleen volume/abdominal volume, longitudinal spleen diameter/longitudinal left kidney diameter and longitudinal spleen diameter/xipho-pubic distance ratios were also calculated.
resultsFor caucasian subjects, in different age groups spleen volume, transverse area and diameter increased while the spleen/abdominal volume ratio decreased significantly (p<0.001). A significant (p<0.001) decrease in longitudinal spleen diameter/xipho-pubic distance ratio was noted between the 0-3 years group and both 4-10 and 11-18 years group. Age and auxological data, except BMI, showed a high correlation with spleen dimension (r≥0.8).
conclusionsThe current concept of splenomegaly is not applicable in pediatric surgery. A dedicated classification of splenomegaly is needed for children and would improve the safety and feasibility of treatment.
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