Trial reportPloS one2018
Stronger prediction of motor recovery and outcome post-stroke by cortico-spinal tract integrity than functional connectivity.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Estimation of Motor Impairment and Usage of Upper Extremities during Daily Living Activities in Poststroke Hemiparesis Patients by Observation of Time Required to Accomplish Hand Dexterity Tasks.BioMed research international · 2019Trial
- Rehabilitation training robot using mirror therapy for the upper and lower limb after stroke: a prospective cohort study.Journal of neuroengineering and rehabilitation · 2025Article
- Microstructure of the residual corticofugal projection from primary motor cortex in chronic stroke.Brain communications · 2025Article
- Differences in motor network reorganization between patients with good and poor upper extremity impairment outcomes after stroke.Brain imaging and behavior · 2024Article
- Brain-Hand Function Relationships Based on Level of Grasp Function in Chronic Left-Hemisphere Stroke.Neurorehabilitation and neural repair · 2024Article
- A Comprehensive Review on the Role of Resting-State Functional Magnetic Resonance Imaging in Predicting Post-Stroke Motor and Sensory Outcomes.Neurology international · 2024Review
- Adaptation of the Concept of Brain Reserve for the Prediction of Stroke Outcome: Proxies, Neural Mechanisms, and Significance for Research.Brain sciences · 2024Article
- Against cortical reorganisation.eLife · 2023Article
- Clinical, Neuroimaging and Robotic Measures Predict Long-Term Proprioceptive Impairments following Stroke.Brain sciences · 2023Article
- Article
- Predictive Factors and Interventional Modalities of Post-stroke Motor Recovery: An Overview.Cureus · 2023Review
- Connectomics underlying motor functional outcomes in the acute period following stroke.Frontiers in aging neuroscience · 2023Article
- Multimodal and multidomain lesion network mapping enhances prediction of sensorimotor behavior in stroke patients.Scientific reports · 2022Article
- Recovery of neural dynamics criticality in personalized whole-brain models of stroke.Nature communications · 2022Article
- Functional connectivity drives stroke recovery: shifting the paradigm from correlation to causation.Brain : a journal of neurology · 2022Review
- No evidence for motor-recovery-related cortical connectivity changes after stroke using resting-state fMRI.Journal of neurophysiology · 2022Article
- Comparing cortico-motor hotspot identification methods in the lower extremities post-stroke: MEP amplitude vs. latency.Neuroscience letters · 2021Observational
- A connectome-based approach to assess motor outcome after neonatal arterial ischemic stroke.Annals of clinical and translational neurology · 2021Article
- Dynamic Structural and Functional Reorganizations Following Motor Stroke.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Relationship Between Body-Specific Attention to a Paretic Limb and Real-World Arm Use in Stroke Patients: A Longitudinal Study.Frontiers in systems neuroscience · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTo examine longitudinal changes in structural and functional connectivity post-stroke in patients with motor impairment, and define their importance for recovery and outcome at 12 months.
methodsFirst-time stroke patients (N = 31) were studied at 1-2 weeks, 3 months, and 12 months post-injury with a validated motor battery and resting-state fMRI to measure inter-hemispheric functional connectivity (FC). Fractional anisotropy (FA) of the cortico-spinal tract (CST) was derived from diffusion tensor imaging as a measure of white matter organization. ANOVAs were used to test for changes in FC, FA, and motor performance scores over time, and regression analysis related motor outcome to clinical and neuroimaging variables.
resultsFA of the ipsilesional CST improved significantly from 3 to 12 months and was strongly correlated with motor performance. FA improved even in the absence of direct damage to the CST. Inter-hemispheric FC also improved over time, but did not correlate with motor performance at 12 months. Clinical variables (early motor score, education level, and age) predicted 80.4% of the variation of motor outcome, and FA increased the predictability to 84.6%. FC did not contribute to the prediction of motor outcome.
conclusionsStroke causes changes to the CST microstructure that can account for behavioral variability even in the absence of demonstrable lesion. Ipsilesional CST undergoes remodeling post-stroke, even past the three-month window when most of the motor recovery happens. FA of the CST, but not inter-hemispheric FC, can improve to the prediction of motor outcome based on early motor scores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.