ArticlePLoS neglected tropical diseases2018
Comparison of the dynamics of Japanese encephalitis virus circulation in sentinel pigs between a rural and a peri-urban setting in Cambodia.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Mosquito vector competence for Japanese encephalitis virus: a systematic review and meta-analysis update.Parasites & vectors · 2025Pooled it
- Australian vertebrate hosts of Japanese encephalitis virus: a review of the evidence.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025Pooled it
- Worldwide impacts of landscape anthropization on mosquito abundance and diversity: A meta-analysis.Global change biology · 2022Pooled it
- Pooled it
- Japanese Encephalitis Vaccine: Recommendations of the Advisory Committee on Immunization Practices.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2019Guideline
- Zoonotic neglected tropical diseases at the animal-human interface in the Greater Mekong Subregion: Two decades of surveillance in Laos and Cambodia.PLoS neglected tropical diseases · 2026Review
- Evidence of Japanese Encephalitis Virus Exposure in Feral Pig Populations in North Queensland, Australia.Transboundary and emerging diseases · 2026Article
- Article
- Report of two severe cases of Japanese encephalitis virus in travelers returning to France, 2023-2024: clinical, diagnostic, and public health implications.ASM case reports · 2025Article
- Epidemiological Features, Clinical Symptoms, and Environmental Risk Factors for Notifiable Japanese Encephalitis in Taiwan From 2008 to 2020: Retrospective Study.JMIR public health and surveillance · 2025Article
- Unique humoral immune response of pigs to repeated natural Japanese encephalitis virus infections: an amplifying host perspective.Archives of virology · 2025Article
- Potential role of heterologous flavivirus immunity in preventing urban transmission of yellow fever virus.Nature communications · 2024Article
- Seroconversion, genotyping, and potential mosquito vector identification of Japanese encephalitis virus in pig sentinel settings in Bali, Indonesia.Veterinary world · 2024Article
- Individual and Herd-Level Seroprevalence in Association with Potential Risk Factors of Japanese Encephalitis in Pigs Collected from Urban, Periurban, and Rural Areas of Bali, Indonesia.Veterinary medicine international · 2023Article
- A biogeographical description of the wild waterbird species associated with high-risk landscapes of Japanese encephalitis virus in India.Transboundary and emerging diseases · 2022Article
- Emerging Genotype IV Japanese Encephalitis Virus Outbreak in New South Wales, Australia.Viruses · 2022Article
- Modelling Japanese encephalitis virus transmission dynamics and human exposure in a Cambodian rural multi-host system.PLoS neglected tropical diseases · 2022Article
- The Ecology and Evolution of Japanese Encephalitis Virus.Pathogens (Basel, Switzerland) · 2021Review
- Japanese Encephalitis in Small-Scale Pig Farming in Rural Cambodia: Pig Seroprevalence and Farmer Awareness.Pathogens (Basel, Switzerland) · 2021Article
- Changes in Rice and Livestock Production and the Potential Emergence of Japanese Encephalitis in Africa.Pathogens (Basel, Switzerland) · 2021Article
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Authors and funding
14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Japanese encephalitis is mainly considered a rural disease, but there is growing evidence of a peri-urban and urban transmission in several countries, including Cambodia. We, therefore, compared the epidemiologic dynamic of Japanese encephalitis between a rural and a peri-urban setting in Cambodia. We monitored two cohorts of 15 pigs and determined the force of infection-rate at which seronegative pigs become positive-in two study farms located in a peri-urban and rural area, respectively. We also studied the mosquito abundance and diversity in proximity of the pigs, as well as the host densities in both areas. All the pigs seroconverted before the age of 6 months. The force of infection was 0.061 per day (95% confidence interval = 0.034-0.098) in the peri-urban cohort and 0.069 per day (95% confidence interval = 0.047-0.099) in the rural cohort. Several differences in the epidemiologic dynamic of Japanese encephalitis between both study sites were highlighted. The later virus amplification in the rural cohort may be linked to the later waning of maternal antibodies, but also to the higher pig density in direct proximity of the studied pigs, which could have led to a dilution of mosquito bites at the farm level. The force of infection was almost identical in both the peri-urban and the rural farms studied, which shifts the classic epidemiologic cycle of the virus. This study is a first step in improving our understanding of Japanese encephalitis virus ecology in different environments with distinct landscapes, human and animal densities.
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