ArticlePloS one2018
Comparison of the molecular characteristics of Mycoplasma pneumoniae from children across different regions of China.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
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- Genomic epidemiology and antimicrobial susceptibility of clinicalFrontiers in cellular and infection microbiology · 2026Article
- The impact of the COVID-19 pandemic on the epidemiology, clinical manifestations and molecular characteristics ofFrontiers in immunology · 2026Review
- Comprehensive study of community acquiredWorld journal of clinical pediatrics · 2025Article
- Recent Macrolide Resistance Pattern of Mycoplasma Pneumonia in the World: A Systematic Review and Meta-Analysis.Iranian journal of public health · 2025Review
- Antimicrobial susceptibility and molecular characteristics ofFrontiers in pediatrics · 2025Article
- Whole-genome probe capture sequencing reveals genomic diversity and characteristics ofFrontiers in microbiology · 2025Article
- New Insights into the Epidemiological Characteristics ofMicroorganisms · 2024Review
- Macrolide resistance ofEpidemiology and infection · 2024Article
- Molecular epidemiology of Mycoplasma pneumoniae pneumonia in children, Wuhan, 2020-2022.BMC microbiology · 2024Article
- Epidemiological, clinical, and genotypic characteristics of pediatricFrontiers in microbiology · 2024Article
- Epidemic characteristics ofAnnals of translational medicine · 2022Article
- Association of Tandem Repeat Number Variabilities in Subunit S of the Type I Restriction-Modification System with Macrolide Resistance inJournal of clinical medicine · 2022Article
- Molecular Tools for TypingFrontiers in microbiology · 2022Review
- Antimicrobial Susceptibility Profiles and Genetic Characteristics ofInfection and drug resistance · 2022Article
- Update on the Epidemiology of Macrolide-ResistantInfectious disease reports · 2021Review
- Consideration in treatment decisions for refractory Mycoplasma pneumoniae pneumonia.Clinical and experimental pediatrics · 2021Article
- Macrolide Resistance, Clinical Features, and Cytokine Profiles in Taiwanese Children WithOpen forum infectious diseases · 2021Article
- Evaluation of the CARDS toxin and its fragment for the serodiagnosis of Mycoplasma pneumoniae infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Mutations in domain V ofThe Journal of international medical research · 2021Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous molecular characterization of Mycoplasma pneumoniae in China focused only on one or two cities. In this study, we characterized 835 samples from patients suspected to be infected with M. pneumoniae; these samples were collected in 2016 from pediatric patients from different regions of China. Multiple locus variable number tandem repeat analysis (MLVA), P1-restriction fragment length polymorphism (RFLP) analysis, and sequencing of the domain V of 23S rRNA were performed to compare genotype distribution across different locations. Two-hundred-and-thirteen samples tested positive for M. pneumoniae by PCR. P1 types were identified in 154 samples: 78.6% were type I and 21.4% were type II. Type I was the most prevalent genotype in five locations, except Nanjing where type II was the most common type (p < 0.01). Five distinct MLVA types were identified in the 172 samples. Genotype M4-5-7-2 was predominant at all locations, except Nanjing where type 3-5-6-2 was the most common (p < 0.01). Macrolide resistance-associated mutations were identified in 186 (76.3%) samples. The resistance rate differed with the location. This study showed that genotypes and macrolide resistance rate differed across China. The most prevalent genotype in China remains M4-5-7-2/P1-1. The resistance rate decreased, along with changes to the M4-5-7-2 genotype.
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