Evidence map›Paper›PMID 30138356›Full record

ArticlePloS one2018

Circulating osteogenic proteins are associated with coronary artery calcification and increase after myocardial infarction.

Antonio E Pesaro, Marcelo Katz, Marcel Liberman, Carolina Pereira, Cristovão L P Mangueira, Ana E Z de Carvalho, Karina S Carvalho, Cesar H Nomura, Marcelo Franken, Carlos V Serrano

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Antonio E PesaroHospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID 0000-0003-3133-4989
Marcelo KatzHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Marcel LibermanHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Carolina PereiraHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Cristovão L P MangueiraHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Ana E Z de CarvalhoHospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID 0000-0001-9246-8839
Karina S CarvalhoHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Cesar H NomuraHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Marcelo FrankenHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Carlos V SerranoHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Hospital Israelita Albert Einstein · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary artery calcification (CAC) and atherosclerotic inflammation associate with increased risk of myocardial infarction (MI). Vascular calcification is regulated by osteogenic proteins (OPs). It is unknown whether an association exists between CAC and plasma OPs and if they are affected by atherothrombotic inflammation. We tested the association of osteogenic and inflammatory proteins with CAC and assessed these biomarkers after MI.

methodsCirculating OPs (osteoprotegerin, RANKL, fetuin-A, Matrix Gla protein [MGP]) and inflammatory proteins (C-reactive protein, oxidized-LDL, tumoral necrosis factor-α, transforming growth factor [TGF]-β1) were compared between stable patients with CAC (CAC ≥ 100 AU, n = 100) and controls (CAC = 0 AU, n = 30). The association between biomarkers and CAC was tested by multivariate analysis. In patients with MI (n = 40), biomarkers were compared between acute phase and 1-2 months post-MI, using controls as a baseline.

resultsMGP and fetuin-A levels were higher within individuals with CAC. Higher levels of MGP and RANKL were associated with CAC (OR 3.12 [95% CI 1.20-8.11], p = 0.02; and OR 1.75 [95% CI 1.04-2.94] respectively, p = 0.035). After MI, C-reactive protein, OPG and oxidized-LDL levels increased in the acute phase, whereas MGP and TGF-β1 increased 1-2 months post-MI.

conclusionsHigher MGP and RANKL levels associate with CAC. These findings highlight the potential role of these proteins as modulators and markers of CAC. In addition, the post-MI increase in OPG and MGP, as well as of inflammatory proteins suggest that the regulation of these OPs is affected by atherothrombotic inflammation.

Indexed as

AdultAgedalpha-2-HS-GlycoproteinBiomarkersCalcium-Binding ProteinsCoronary Artery DiseaseC-Reactive ProteinExtracellular Matrix ProteinsFemaleHumansLipoproteins, LDLMaleMatrix Gla ProteinMiddle AgedMyocardial InfarctionOsteoprotegerinAHSG protein, humanalpha-2-HS-GlycoproteinBiomarkersCalcium-Binding ProteinsC-Reactive ProteinExtracellular Matrix ProteinsLipoproteins, LDLMatrix Gla ProteinOsteoprotegerinoxidized low density lipoproteinRANK LigandTGFB1 protein, humanTNF protein, humanTNFSF11 protein, humanTransforming Growth Factor beta1Tumor Necrosis Factor-alpha

Identifiers

PMID30138356
PMCPMC6107213
OpenAlexW2888250437

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.