Evidence map›Paper›PMID 30138104›Full record

ReviewBiological chemistry2018

Cold atmospheric plasma is a viable solution for treating orthopedic infection: a review.

Ly Nguyen, Peng Lu, Daniela Boehm, Paula Bourke, Brendan F Gilmore, Noreen J Hickok, Theresa A Freeman

Abstract readReview
In one paragraph

Review in Biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ly NguyenDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107-5099, USA.
Peng LuCollege of Science and Health, Dublin Institute of Technology, Dublin, Ireland.
Daniela BoehmCollege of Science and Health, Dublin Institute of Technology, Dublin, Ireland.
Paula BourkeCollege of Science and Health, Dublin Institute of Technology, Dublin, Ireland.
Brendan F GilmoreSchool of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Noreen J HickokDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107-5099, USA.
Theresa A FreemanDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107-5099, USA.ORCID http://orcid.org/0000-0002-5959-5884
Thomas Jefferson University · USQueen's University Belfast · GB

Funding

Plasma-based therapies for bone infection: A tripartite USA/Northern Ireland/Republic of Ireland consortiumR01AR076941 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI BOURKE, PAULA, FREEMAN, THERESA A · 2020 to 2025
$3.3M
Preventing Spinal Infection: Ultrasound Triggered ProphylaxisR01AR069119 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI Flemming Forsberg, Noreen J Hickok · 2016 to 2026
$3.2M
Smart Substrates for a New Generation of ImplantsR01AR051303 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI SHAPIRO, IRVING M · 2005 to 2009
$3.1M
Synovial Fluid and Joint SepsisR01AR072513 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI HICKOK, NOREEN J · 2017 to 2021
$2.5M
Non-Thermal Plasma in Biomedicine: A New Paradigm for Redox Cell ActivationR01EB013011 · NIBIB · THOMAS JEFFERSON UNIVERSITY · PI FREEMAN, THERESA A · 2011 to 2014
$1.4M
Biotechnology and Biological Sciences Research Council BB/P008496/1NIAMS NIH HHS R01 AR051303NIAMS NIH HHS R01 AR069119NIAMS NIH HHS R01 AR072513NIAMS NIH HHS R01 AR076941NIBIB NIH HHS R01 EB013011
6 · The paper itself

Abstract

Bacterial infection and antibiotic resistance are major threats to human health and very few solutions are available to combat this eventuality. A growing number of studies indicate that cold (non-thermal) plasma treatment can be used to prevent or eliminate infection from bacteria, bacterial biofilms, fungi and viruses. Mechanistically, a cold plasma discharge is composed of high-energy electrons that generate short-lived reactive oxygen and nitrogen species which further react to form more stable compounds (NO2, H2O2, NH2Cl and others) depending on the gas mixture and plasma parameters. Cold plasma devices are being developed for medical applications including infection, cancer, plastic surgery applications and more. Thus, in this review we explore the potential utility of cold plasma as a non-antibiotic approach for treating post-surgical orthopedic infections.

Indexed as

Antigens, BacterialBacterial InfectionsBiofilmsExtracellular MatrixHumansOrthopedic ProceduresPlasma GasesReactive Nitrogen SpeciesReactive Oxygen SpeciesSurgical Wound InfectionAntigens, BacterialPlasma GasesReactive Nitrogen SpeciesReactive Oxygen Speciesbacteriabiofilmcold plasmaorthopedic infectionStaphylococcus aureustitanium

Identifiers

PMID30138104
PMCPMC12105529
OpenAlexW2888055265

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.