Evidence map›Paper›PMID 30137877›Full record

ArticleCognitive neurodynamics2018

Maintenance of postsynaptic neuronal excitability by a positive feedback loop of postsynaptic BDNF expression.

Lijie Hao, Zhuoqin Yang, Pulin Gong, Jinzhi Lei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cognitive neurodynamics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. The Effect of Beta-Boswellic Acid on the Expression ofAdvanced pharmaceutical bulletin · 2020
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lijie Hao1School of Mathematics and Systems Science and LMIB, Beihang University, Beijing, 100191 China.
Zhuoqin Yang1School of Mathematics and Systems Science and LMIB, Beihang University, Beijing, 100191 China.
Pulin Gong2School of Physics, University of Sydney, Sydney, NSW 2006 Australia.
Jinzhi Lei3Zhou Pei-Yuan Center for Applied Mathematics, MOE Key Laboratory of Bioinformatics, Tsinghua University, Beijing, 100084 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experiments have demonstrated that in mice, the PVT strongly projects to the CeL and participates in the formation of fear memories by synaptic potentiation in the amygdala. Herein, we propose a mathematical model based on a positive feedback loop of BDNF expression and signaling to investigate PVT manipulation of synaptic potentiation. The model is validated by comparisons with experimental observations. We find that a high postsynaptic firing frequency after stimulation is induced by presynaptic

Indexed as

Fear conditioningFiring frequencyPositive feedbackPresynapticSynaptic potentiation

Identifiers

PMID30137877
PMCPMC6048012

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.