Evidence map›Paper›PMID 30137695›Full record

ArticleInfluenza and other respiratory viruses2019

"Differential risk of hospitalization among single virus infections causing influenza-like illnesses".

Ana A Ortiz-Hernández, Katherine K Nishimura, Daniel E Noyola, Sarbelio Moreno-Espinosa, Ana Gamiño, Arturo Galindo-Fraga, Rafael Valdéz Vázquez, Martín Magaña Aquino, Alejandra Ramirez-Venegas, Raydel Valdés Salgado and 10 more

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Influenza and other respiratory viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Increased Detection of Viruses in Children with Respiratory Tract Infection Using PCR.International journal of environmental research and public health · 2020
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 2 countries.

Ana A Ortiz-HernándezInstituto Nacional de Pediatria, Ciudad de México, México.ORCID 0000-0001-6505-0066
Katherine K NishimuraNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Daniel E NoyolaUniversidad Autonoma de San Luis Potosi, San Luis Potosí, México.ORCID 0000-0002-4840-6742
Sarbelio Moreno-EspinosaHospital Infantil de México Dr. Federico Gómez, Ciudad de México, México.
Ana GamiñoHospital Infantil de México Dr. Federico Gómez, Ciudad de México, México.
Arturo Galindo-FragaInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Ciudad de México, México.
Rafael Valdéz VázquezHospital General Dr. Manuel Gea González, Ciudad de México, México.
Martín Magaña AquinoHospital Regional Dr. Ignacio Morones Prieto, San Luis Potosí, México.
Alejandra Ramirez-VenegasInstituto Nacional de Enfermedades Respiratorias, Ciudad de México, México.
Raydel Valdés SalgadoWestat, Rockville, Maryland.
Diana Andrade-PlatasInstituto Nacional de Pediatria, Ciudad de México, México.
Juliana Estevez-JimenézInstituto Nacional de Pediatria, Ciudad de México, México.
Guillermo M Ruiz-PalaciosInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Ciudad de México, México.
Maria Lourdes GuerreroInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Ciudad de México, México.
John BeigelFrederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland.ORCID 0000-0002-4879-4941
Mary C SmolskisNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Sally HunsbergerNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Laura Freimanis-HenceWestat, Rockville, Maryland.
Beatriz Llamosas-GallardoInstituto Nacional de Pediatria, Ciudad de México, México.ORCID 0000-0002-3945-7476
Mexico Emerging Infectious Diseases Clinical Research Network (La Red)
Instituto Nacional de Pediatria · MXInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXNational Institutes of Health · USHospital Infantil de México Federico Gómez · MXWestat (United States) · USAutonomous University of San Luis Potosí · MXHospital Central Dr. Ignacio Morones Prieto · MXHospital General Dr. Manuel Gea Gonzalez · MXInstituto Nacional de Enfermedades Respiratorias · MXLeidos (United States) · US

Funding

CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENIAID NIH HHS HHSN272200900001CNIAID NIH HHS HHSN272200900031C
6 · The paper itself

Abstract

backgroundAcute respiratory infections are a major cause of morbidity in children and are often caused by viruses. However, the relative severity of illness associated with different viruses is unclear. The objective of this study was to evaluate the risk of hospitalization from different viruses in children presenting with an influenza-like illness (ILI).

methodsData from children 5 years old or younger participating in an ILI natural history study from April 2010 to March 2014 was analyzed. The adjusted odds ratio for hospitalization was estimated in children with infections caused by respiratory syncytial virus (RSV), metapneumovirus, bocavirus, parainfluenza viruses, rhinovirus/enterovirus, coronavirus, adenovirus, and influenza.

resultsA total of 1486 children (408 outpatients and 1078 inpatients) were included in this analysis. At least one virus was detected in 1227 (82.6%) patients. The most frequent viruses detected as single pathogens were RSV (n = 286), rhinovirus/enterovirus (n = 251), parainfluenza viruses (n = 104), and influenza A or B (n = 99). After controlling for potential confounders (age, sex, recruitment site, days from symptom onset to enrollment, and underlying illnesses), children with RSV and metapneumovirus infections showed a greater likelihood of hospitalization than those infected by parainfluenza viruses (OR 2.7 and 1.9, respectively), rhinovirus/enterovirus (OR 3.1 and 2.1, respectively), coronaviruses (OR 4.9 and 3.4, respectively), adenovirus (OR 4.6 and 3.2, respectively), and influenza (OR 6.3 and 4.4, respectively).

conclusionsChildren presenting with ILI caused by RSV and metapneumovirus were at greatest risk for hospitalization, while children with rhinovirus/enterovirus, parainfluenza, coronavirus, adenovirus, and influenza were at lower risk of hospitalization.

Indexed as

Acute DiseaseChild, PreschoolFemaleHospitalizationHumansInfantInfluenza, HumanMaleMexicoOdds RatioParamyxoviridae InfectionsProspective StudiesRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsSeverity of Illness IndexVirus Diseasesacute respiratory infectionhospitalizationinfluenza-like illnesssingle virus

Identifiers

PMID30137695
PMCPMC6304313
OpenAlexW2888027417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.