Evidence map›Paper›PMID 30137588›Full record

ArticleRheumatology (Oxford, England)2018

Approach to evaluating pregnancy safety of anti-rheumatic medications in the OTIS MotherToBaby pregnancy studies: what have we learned?

Christina Chambers, Diana L Johnson, Elizabeth Kiernan

Abstract read
In one paragraph

Article in Rheumatology (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Maternal beliefs and asthma medication adherence during pregnancy.The journal of allergy and clinical immunology. Global · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Clinical considerations for the management of psoriasis in women.International journal of women's dermatology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christina ChambersDepartment of Pediatrics, Division of Dysmorphology and Teratology, University of California San Diego, La Jolla, CA, USA.
Diana L JohnsonDepartment of Pediatrics, Division of Dysmorphology and Teratology, University of California San Diego, La Jolla, CA, USA.
Elizabeth KiernanDepartment of Pediatrics, Division of Dysmorphology and Teratology, University of California San Diego, La Jolla, CA, USA.

Funding

International Conference on Reproduction, Pregnancy, and Rheumatic DiseaseR13AR070007 · NIAMS · DUKE UNIVERSITY · PI CLOWSE, MEGAN E.B. · 2016 to 2016
$15k
NIAMS NIH HHS R13 AR070007
6 · The paper itself

Abstract

For the last 30 years, pregnancy exposure studies, with varying methodologies, have been the mainstay of post-marketing surveillance for new drugs likely to be used by women of reproductive age. While they provide valuable data to inform use during pregnancy, they have limitations that render them necessary but not sufficient in supplying timely information to patients and prescribers. The Organization of Teratology Information Specialists MotherToBaby Pregnancy Studies' collaborative research group operates to help fill this gap. This paper provides an overview of the research that has been and is currently being conducted, as well as best practices determined over the past two decades. The Organization of Teratology Information Specialists MotherToBaby studies can provide earlier signaling with regard to concerns following possible teratogenic exposures, which when examined in conjunction with larger database studies and case-control designs, can move us closer to developing a fuller picture of drug safety for women of reproductive age.

Indexed as

Maternal ExposureAntirheumatic AgentsCase-Control StudiesFemaleHumansPregnancyPregnancy ComplicationsProspective StudiesRheumatic DiseasesTeratogensTeratologyAntirheumatic AgentsTeratogens

Identifiers

PMID30137588
PMCPMC6099128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.