Evidence map›Paper›PMID 30137584›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2018

Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA.

Nicholas M Selby, Peter J Blankestijn, Peter Boor, Christian Combe, Kai-Uwe Eckardt, Eli Eikefjord, Nuria Garcia-Fernandez, Xavier Golay, Isky Gordon, Nicolas Grenier and 24 more

5 registry-linked trialsAbstract readConsensus Statement
In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 86 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03723512 nacompletednot on this map

Sub-project of the Clinical Protocol ACH471-205 "An Open-Label Phase 2 Proof-of-Concept Study in Patients With C3 Glomerulopathy (C3G) or Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN) Treated With ACH-0144471"

TypeinterventionalSponsorMario Negri Institute for Pharmacological ResearchRan2018 to 2021Enrolled7ConditionsC3 Glomerulonephritis, C3 Glomerulopathy, Immune Complex Membranoproliferative Glomerulonephritis, IC-MPGNArmsNon contrast-enhanced magnetic resonance imaging
NCT06210555 recruitingnot on this mapstarted 2024, after this paper: background citation

Multiparametric MRI in a Prospective Cohort of Living Kidney Donors, Recipients, and Healthy Controls: Correlations With Markers of Renal Function, Fibrosis and Ageing

TypeobservationalSponsorPatrick SchjelderupRan2024 to 2029Enrolled96ConditionsKidney Transplantation, Multiparametric Magnetic Resonance Imaging, Living Donors, Renal FibrosisArmsRenal transplantation, Living kidney donation
NCT06325488 recruitingnot on this mapstarted 2024, after this paper: background citation

Fibrosis, Inflammation, Oxygenation of Renal Tissue In FabrY Disease

TypeobservationalSponsorCaroline Michaela KistorpRan2024 to 2026Enrolled60ConditionsFabry Disease, Chronic Kidney Diseases
NCT06884410 narecruitingnot on this mapstarted 2025, after this paper: background citation

Reproducibility of Multiparametric Renal Magnetic Resonance Imaging on 1.5T MRI Scanners (RESPECT_1.5T Sub-study)

TypeinterventionalSponsorMario Negri Institute for Pharmacological ResearchRan2025 to 2026Enrolled48ConditionsMultiparametric MRIArmsMRI
NCT07175051 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2026 to 2030Enrolled20ConditionsSickle Cell Anemia (HbSS, or HbSβ-thalassemia0), AlbuminuriaArmsEmpagliflozin (oral)
3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation: a statement paper and systematic review.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018
    Pooled it
  3. Trial
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  7. Multiparametric MR Imaging for Evaluating Renal Function and Microstructure.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Review
  8. Article
  9. Review
  10. Review
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  13. Review
  14. Rationale, design and baseline characteristics of REMODEL, a mechanism-of-action trial with semaglutide in people with type 2 diabetes and chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  15. Article
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  18. Article
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  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors.

Nicholas M SelbyCentre for Kidney Research and Innovation, University of Nottingham, UK.
Peter J BlankestijnNephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Peter BoorInstitute of Pathology and Department of Nephrology, RWTH University, Aachen, Germany.
Christian CombeService de Néphrologie Transplantation Dialyse Aphérèse, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
Kai-Uwe EckardtDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Eli EikefjordDepartment of Health and Functioning, Western Norway University of Applied Sciences, Norway.
Nuria Garcia-FernandezService of Nephrology, Clinica Universidad de Navarra, Pamplona, Spain.
Xavier GolayInstitute of Neurology, University College London, Queen Square, London, UK.
Isky GordonGreat Ormond Street Institute of Child Health, University College London, London, UK.
Nicolas GrenierService d'Imagerie Diagnostique et Interventionnelle de l'Adulte, Centre Hospitalier Universitaire de Bordeaux Place Amelie Raba-Leon, Bordeaux, France.
Paul D HockingsAntaros Medical, BioVenture Hub, Mölndal, Sweden.
Jens D JensenDepartments of Renal and Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Jaap A JolesNephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Philip A KalraDepartment of Renal Medicine, Salford Royal Hospital and Division of Cardiovascular Sciences, University of Manchester, Manchester, UK.
Bernhard K KrämerVth Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim of the University Heidelberg, Mannheim, Germany.
Patrick B MarkInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Iosif A MendichovszkyDepartment of Radiology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK.
Olivera NikolicFaculty of Medicine,University of Novi Sad, Center of Radiology, Clinical Centre of Vojvodina, Serbia.
Aghogho OduduDivision of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Albert C M OngAcademic Nephrology Unit, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.
Alberto OrtizNephrology and Hypertension, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain.
Menno PruijmService of Nephrology and Hypertension, Department of Medicine, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Giuseppe RemuzziIRCCS Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.
Jarle RørvikDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Sophie de SeigneuxService of Nephrology, Department of Medicine Specialties, University Hospital of Geneva, Geneva, Switzerland.
Roslyn J SimmsAcademic Nephrology Unit, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.
Janka SlatinskaDepartment of Nephrology, Transplant Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Paul SummersDepartment of Medical Imaging and Radiation Sciences, Radiology Division, European Institute of Oncology (IEO), Milan, Italy.
Maarten W TaalCentre for Kidney Research and Innovation, University of Nottingham, UK.
Harriet C ThoenyUniversity of Bern, Inselspital, Bern, Switzerland.
Jean-Paul ValléeRadiology Department, Geneva University Hospital and University of Geneva, Geneva, Switzerland.
Marcos WolfCenter for Medical Physics and Biomedical Engineering, MR-Centre of Excellence, Medical University of Vienna, Vienna, Austria.
Anna CaroliIRCCS Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.
Steven SourbronLeeds Imaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, UK.

Funding

Austrian Science Fund FWF P 28867
6 · The paper itself

Abstract

Functional renal magnetic resonance imaging (MRI) has seen a number of recent advances, and techniques are now available that can generate quantitative imaging biomarkers with the potential to improve the management of kidney disease. Such biomarkers are sensitive to changes in renal blood flow, tissue perfusion, oxygenation and microstructure (including inflammation and fibrosis), processes that are important in a range of renal diseases including chronic kidney disease. However, several challenges remain to move these techniques towards clinical adoption, from technical validation through biological and clinical validation, to demonstration of cost-effectiveness and regulatory qualification. To address these challenges, the European Cooperation in Science and Technology Action PARENCHIMA was initiated in early 2017. PARENCHIMA is a multidisciplinary pan-European network with an overarching aim of eliminating the main barriers to the broader evaluation, commercial exploitation and clinical use of renal MRI biomarkers. This position paper lays out PARENCHIMA's vision on key clinical questions that MRI must address to become more widely used in patients with kidney disease, first within research settings and ultimately in clinical practice. We then present a series of practical recommendations to accelerate the study and translation of these techniques.

Indexed as

BiomarkersDisease ProgressionHumansMagnetic Resonance ImagingRenal Insufficiency, ChronicBiomarkers

Identifiers

PMID30137584
PMCPMC6106645

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.