SynthesisNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2018
Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation: a statement paper and systematic review.
Synthesis in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 80 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Roxadustat on the Levels of Renal Oxygenation in Patients With Diabetes Nephropathy (FOXTROT)
Fibrosis, Inflammation, Oxygenation of Renal Tissue In FabrY Disease
Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin
Who cites it
80 citing papers in PubMed, 4 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- Multiparametric functional MRI for detection of early renal allograft dysfunction after kidney transplantation: a systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- Phase-contrast magnetic resonance imaging to assess renal perfusion: a systematic review and statement paper.Magma (New York, N.Y.) · 2020Pooled it
- Arterial spin labelling MRI to measure renal perfusion: a systematic review and statement paper.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Pooled it
- Magnetic resonance imaging T1- and T2-mapping to assess renal structure and function: a systematic review and statement paper.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Pooled it
- Atherosclerotic Renovascular Disease: A Re-evaluation of Lesion Severity and Intervention.Kidney medicine · 2026Review
- Multiparametric MR Imaging for Evaluating Renal Function and Microstructure.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Review
- Glomerulonephritis through the lens of ultrasound and radiology.World journal of nephrology · 2026Review
- Renal R2* as a noninvasive predictor of hepatorenal syndrome-acute kidney disease in cirrhotic patients with ascites: a retrospective cohort study.Quantitative imaging in medicine and surgery · 2026Article
- Automated Coregistered Segmentation for Volumetric Analysis of Multiparametric Renal MRI.Magnetic resonance in medicine · 2026Article
- Multimodal Magnetic Resonance Imaging in Diabetic Kidney Disease: From Pathophysiological Insights to Clinical Applications.Diagnostics (Basel, Switzerland) · 2026Review
- Contrast-free functional MRI for assessing renal involvement in patients with ANCA-associated vasculitis.BMC nephrology · 2026Article
- Multiparametric MRI for Predicting Renal Function Deterioration and Chronic Kidney Disease Development in Patients Undergoing Nephrectomy for Renal Masses: A Pilot Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Evaluation of the direct effect of remote ischemic preconditioning on the rabbit's kidney by RBMC medical imaging · 2026Article
- Progress of functional magnetic resonance imaging in the assessment of transplanted kidney function.Renal failure · 2025Review
- Effect of posture on renal volume: evaluation using multi-posture MRI.Radiological physics and technology · 2025Article
- Assessment of renal insufficiency in patients with renal artery stenosis by multiparametric magnetic resonance imaging.Renal failure · 2025Article
- Medullary sponge kidney: in-depth phenotyping for a better understanding of functional and structural abnormalities.Journal of nephrology · 2025Article
- Article
- A method to measure renal inner medullary perfusion using MR renography.Magma (New York, N.Y.) · 2025Article
- Mapping the arterial vascular network in an intact human kidney using hierarchical phase-contrast tomography.Npj imaging · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 7 countries.
Funding
Abstract
Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action 'Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease' (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.