Evidence map›Paper›PMID 30137550›Full record

ArticleSocial cognitive and affective neuroscience2018

Mixed support for a causal link between single dose intranasal oxytocin and spiritual experiences: opposing effects depending on individual proclivities for absorption.

Diana S Cortes, Michael Skragge, Lillian Döllinger, Petri Laukka, Håkan Fischer, Mats E Nilsson, Daniel Hovey, Lars Westberg, Marcus Larsson, Pehr Granqvist

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Social cognitive and affective neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Diana S CortesStockholm University, Department of Psychology.
Michael SkraggeStockholm University, Department of Psychology.
Lillian DöllingerStockholm University, Department of Psychology.
Petri LaukkaStockholm University, Department of Psychology.
Håkan FischerStockholm University, Department of Psychology.
Mats E NilssonStockholm University, Department of Psychology.
Daniel HoveyUniversity of Gotheburg, Institute of Neuroscience and Physiology at the Sahlgrenska Academy, Department of Pharmacology.
Lars WestbergUniversity of Gotheburg, Institute of Neuroscience and Physiology at the Sahlgrenska Academy, Department of Pharmacology.
Marcus LarssonLund University, Pediatric Medicine.
Pehr GranqvistStockholm University, Department of Psychology.
Stockholm University · SEUniversity of Gothenburg · SELund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intranasal oxytocin (OT) has previously been found to increase spirituality, an effect moderated by OT-related genotypes. This pre-registered study sought to conceptually replicate and extend those findings. Using a single dose of intranasal OT vs placebo (PL), we investigated experimental treatment effects, and moderation by OT-related genotypes on spirituality, mystical experiences, and the sensed presence of a sentient being. A more exploratory aim was to test for interactions between treatment and the personality disposition absorption on these spirituality-related outcomes. A priming plus sensory deprivation procedure that has facilitated spiritual experiences in previous studies was used. The sample (N = 116) contained both sexes and was drawn from a relatively secular context. Results failed to conceptually replicate both the main effects of treatment and the treatment by genotype interactions on spirituality. Similarly, there were no such effects on mystical experiences or sensed presence. However, the data suggested an interaction between treatment and absorption. Relative to PL, OT seemed to enhance spiritual experiences in participants scoring low in absorption and dampen spirituality in participants scoring high in absorption.

Indexed as

SpiritualityAdministration, IntranasalAdultDNAFemaleGenotypeHumansIndividualityMaleNasal MucosaOxytocinReceptors, OxytocinYoung AdultDNAOxytocinReceptors, Oxytocin

Identifiers

PMID30137550
PMCPMC6137319
OpenAlexW2888413876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.