Evidence map›Paper›PMID 30137262›Full record

Trial reportCerebral cortex (New York, N.Y. : 1991)2019

Analgesic Effects Evoked by Real and Imagined Acupuncture: A Neuroimaging Study.

Jin Cao, Yiheng Tu, Scott P Orr, Courtney Lang, Joel Park, Mark Vangel, Lucy Chen, Randy Gollub, Jian Kong

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07197710 (Assessing the Efficacy of Imagined Acupuncture for Postoperative Acute Pain Management in Spinal Surgery), which is not on this map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07197710 narecruitingnot on this mapstarted 2025, after this paper: background citation

Assessing the Efficacy of Imagined Acupuncture for Postoperative Acute Pain Management in Spinal Surgery

TypeinterventionalSponsorJingping Wang, MD, Ph.D.Ran2025 to 2026Enrolled120ConditionsPain ManagementArmsvideo-guided acupuncture imagery treatment (VGAIT), Education video
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Cognitive components of acupuncture treatment.Integrative medicine research · 2021
    Article
  14. Article
  15. Article
  16. Acupuncture Can Play an Antidepressant Role by Regulating the Intestinal Microbes and Neurotransmitters in a Rat Model of Depression.Medical science monitor : international medical journal of experimental and clinical research · 2021
    Article
  17. Review
  18. Article
  19. Review
  20. Cognition and Pain: A Review.Frontiers in psychology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jin CaoDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Yiheng TuDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Scott P OrrDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Courtney LangDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Joel ParkDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Mark VangelDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Lucy ChenDepartment of Anesthesia, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Randy GollubDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Jian KongDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Harvard University · USMassachusetts General Hospital · USAthinoula A. Martinos Center for Biomedical Imaging · US

Funding

Neuromodulation of placebo and nocebo effectsR01AT008563 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2015 to 2019
$3.9M
Modulation effects of imagined acupuncture and no touch placebo acupunctureR33AT009310 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2018 to 2021
$2.7M
Mechanistic Studies on video guided acupuncture imagery treatment of painR61AT009310 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2016 to 2017
$845k
Neural dynamics of directly and indirectly conditioned placebo/nocebo effectR21AT008707 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2016 to 2017
$479k
NCCIH NIH HHS R21 AT008707NCCIH NIH HHS R33 AT009310NCCIH NIH HHS R61 AT009310
6 · The paper itself

Abstract

Acupuncture can provide therapeutic analgesic benefits but is limited by its cost and scheduling difficulties. Guided imagery is a commonly used method for treating many disorders, such as chronic pain. The present study examined a novel intervention for pain relief that integrates acupuncture with imagery called video-guided acupuncture imagery treatment (VGAIT). A total of 27 healthy subjects were recruited for a crossover-design study that included 5 sessions administered in a randomized order (i.e., baseline and 4 different interventions). We investigated changes in pain threshold and fMRI signals modulated by: 1) VGAIT, watching a video of acupuncture previously administered on the participant's own body at baseline while imagining it being concurrently applied; 2) a VGAIT control condition, watching a video of a cotton swab touching the skin; 3) real acupuncture; and 4) sham acupuncture. Results demonstrated that real acupuncture and VGAIT significantly increased pain threshold compared with respective control groups. Imaging showed that real acupuncture produced greater activation of the insula compared with VGAIT. VGAIT produced greater deactivation at the rostral anterior cingulate cortex. Our findings demonstrate that VGAIT holds potential clinical value for pain management.

Indexed as

Pain ThresholdVideo RecordingAcupuncture AnalgesiaAdultBrainCerebral CortexChronic PainCross-Over StudiesFemaleFunctional NeuroimagingGyrus CinguliHealthy VolunteersHumansImagery, PsychotherapyMagnetic Resonance ImagingMalePlacebosacupuncture analgesiachronic painfMRIimageryvideo-guided acupuncture imagery treatment

Identifiers

PMID30137262
PMCPMC7302519
OpenAlexW2888344675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.