Evidence map›Paper›PMID 30137203›Full record

ArticleAmerican journal of epidemiology2018

Ischemic Heart Disease Mortality and Diesel Exhaust and Respirable Dust Exposure in the Diesel Exhaust in Miners Study.

Sadie Costello, Michael D Attfield, Jay H Lubin, Andreas M Neophytou, Aaron Blair, Daniel M Brown, Patricia A Stewart, Roel Vermeulen, Ellen A Eisen, Debra T Silverman

Open access · bronzeAbstract read
In one paragraph

Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sadie CostelloDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California.
Michael D AttfieldOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Jay H LubinBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Andreas M NeophytouDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California.
Aaron BlairOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Daniel M BrownDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California.
Patricia A StewartStewart Exposure Assessments, LLC, Arlington, Virginia.
Roel VermeulenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Ellen A EisenDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California.
Debra T SilvermanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
University of California, Berkeley · USDivision of Cancer Epidemiology and GeneticsNational Cancer Institute · USUtrecht University · NL

Funding

Targeted Research Training CoreT42OH008429 · OH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRIS ADAMSON, CARISA · 2005 to 2024
$30.0M
NIOSH CDC HHS T42 OH008429
6 · The paper itself

Abstract

Diesel exhaust is a suggested risk factor for ischemic heart disease (IHD), but evidence from cohorts using quantitative exposure metrics is limited. We examined the impact of respirable elemental carbon (REC), a key surrogate for diesel exhaust, and respirable dust (RD) on IHD mortality, using data from the Diesel Exhaust in Miners Study in the United States. Using data from a cohort of male workers followed from 1948-1968 until 1997, we fitted Cox proportional hazards models to estimate hazard ratios for IHD mortality for cumulative and average intensity of exposure to REC and RD. Segmented linear regression models allowed for nonmonotonicity. Hazard ratios for cumulative and average REC exposure declined relative to the lowest exposure category before increasing to 0.79 and 1.25, respectively, in the highest category. Relative to the category containing the segmented regression change points, hazard ratios for the highest category were 1.69 and 1.54 for cumulative and average REC exposure, respectively. Hazard ratios for RD exposure increased across the full exposure range to 1.33 and 2.69 for cumulative and average RD exposure, respectively. Tests for trend were statistically significant for cumulative REC exposure (above the change point) and for average RD exposure. Our findings suggest excess risk of IHD mortality in relation to increased exposure to REC and RD.

Indexed as

AdultAir Pollutants, OccupationalCarbonCoal MiningCohort StudiesDustEnvironmental MonitoringHumansInhalation ExposureMaleMiddle AgedMinersMyocardial IschemiaOccupational ExposureProportional Hazards ModelsRisk FactorsAir Pollutants, OccupationalCarbonDustVehicle Emissions

Identifiers

PMID30137203
PMCPMC6269247
OpenAlexW2888095745

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.