ArticlePhysiological reports2018
Exercise-heat stress with and without water replacement alters brain structures and impairs visuomotor performance.
Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Effects of aerobic exercise on executive function among overweight and obese children: a systematic review and meta-analysis.Frontiers in psychology · 2024Pooled it
- Physical activity on executive function in sedentary individuals: Systematic review and meta-analysis of randomized controlled trials.PloS one · 2023Pooled it
- Effects of hypohydration and fluid balance in athletes' cognitive performance: a systematic review.African health sciences · 2022Pooled it
- Multimodal MRI local metrics and cognitive performance following water intake in 12-h water-restricted adults: a randomized controlled trial.Frontiers in nutrition · 2026Trial
- Hypohydration alters pre-frontal cortex haemodynamics, but does not impair motor learning.Experimental brain research · 2022Trial
- Different Amounts of Water Supplementation Improved Cognitive Performance and Mood among Young Adults after 12 h Water Restriction in Baoding, China: A Randomized Controlled Trial (RCT).International journal of environmental research and public health · 2020Trial
- Perspectives on enhancing human performance in the heat: Is the solution to simply "just add water"?Sports medicine and health science · 2025Review
- Exploring the relationship between larmor-frequency electrical conductivity, diffusivity, and tissue volume in the aging brain.Quantitative imaging in medicine and surgery · 2025Article
- Co-administration of Nanowired Oxiracetam and Neprilysin with Monoclonal Antibodies to Amyloid Beta Peptide and p-Tau Thwarted Exacerbation of Brain Pathology in Concussive Head Injury at Hot Environment.Advances in neurobiology · 2023Review
- Corticospinal and peripheral responses to heat-induced hypo-hydration: potential physiological mechanisms and implications for neuromuscular function.European journal of applied physiology · 2022Review
- Wearable Sensors and Machine Learning for Hypovolemia Problems in Occupational, Military and Sports Medicine: Physiological Basis, Hardware and Algorithms.Sensors (Basel, Switzerland) · 2022Review
- Article
- Proposed framework for forecasting heat-effects on motor-cognitive performance in the Summer Olympics.Temperature (Austin, Tex.) · 2021Article
- Hyperthermia, but not dehydration, alters the electrical activity of the brain.European journal of applied physiology · 2020Article
- Assessment of Heat Stress Exposure among Construction Workers in the Hot Desert Climate of Saudi Arabia.Annals of work exposures and health · 2019Article
- Pre-Exercise Rehydration Attenuates Central Fatigability during 2-Min Maximum Voluntary Contraction in Hyperthermia.Medicina (Kaunas, Lithuania) · 2019Article
- Heat, Hydration and the Human Brain, Heart and Skeletal Muscles.Sports medicine (Auckland, N.Z.) · 2019Review
- Exercise-heat stress with and without water replacement alters brain structures and impairs visuomotor performance.Physiological reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effects of exercise-heat stress with and without water replacement on brain structure and visuomotor performance were examined. Thirteen healthy adults (23.6 ± 4.2 years) completed counterbalanced 150 min trials of exercise-heat stress (45°C, 15% RH) with water replacement (EHS) or without (~3% body mass loss; EHS-DEH) compared to seated rest (CON). Anatomical scans and fMRI Blood-Oxygen-Level-Dependent responses during a visuomotor pacing task were evaluated. Accuracy decreased (P < 0.05) despite water replacement during EHS (-8.2 ± 6.8% vs. CON) but further degraded with EHS-DEH (-8.3 ± 6.4% vs. EHS and -16.5 ± 10.2% vs. CON). Relative to CON, EHS elicited opposing volumetric changes (P < 0.05) in brain ventricles (-5.3 ± 1.7%) and periventricular structures (cerebellum: 1.5 ± 0.8%) compared to EHS-DEH (ventricles: 6.8 ± 3.4, cerebellum: -0.7 ± 0.7; thalamus: -2.7 ± 1.3%). Changes in plasma osmolality (EHS: -3.0 ± 2.1; EHS-DEH: 9.3 ± 2.1 mOsm/kg) were related (P < 0.05) to thalamus (r = -0.45) and cerebellum volume (r = -0.61) which, in turn, were related (P < 0.05) to lateral (r = -0.41) and fourth ventricle volume (r = -0.67) changes, respectively; but, there were no associations (P > 0.50) between structural changes and visuomotor accuracy. EHS-DEH increased neural activation (P < 0.05) within motor and visual areas versus EHS and CON. Brain structural changes are related to bidirectional plasma osmolality perturbations resulting from exercise-heat stress (with and without water replacement), but do not explain visuomotor impairments. Negative impacts of exercise-heat stress on visuomotor tasks are further exacerbated by dehydration.
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Registered trials
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