ArticleIrish journal of medical science2019
Irrational use of proton pump inhibitors in general practise.
Article in Irish journal of medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Lansoprazole for persistent throat symptoms in secondary care: the TOPPITS RCT.Health technology assessment (Winchester, England) · 2021Trial
- Effects of the Nudge Theory-Based Multifaceted Intervention on Reducing Inappropriate Proton Pump Inhibitors Use for Prophylaxis in Hospitalized Patients: A Non-Randomized Controlled Study.Journal of general internal medicine · 2025Article
- Appropriate Use of Proton Pump Inhibitors in General Out Patient Department of a Tertiary Care Center of Kathmandu Valley: An Observational Study.JNMA; journal of the Nepal Medical Association · 2025Observational
- Analysis of inappropriate prophylactic use of proton pump inhibitors during the perioperative period: an observational study.Perioperative medicine (London, England) · 2024Article
- The roles and patterns of critical care pharmacists: a literature review and practical operation model in China.Frontiers in pharmacology · 2024Review
- Proton pump inhibitors in inpatients: Are we getting it right? A retrospective analysis.Qatar medical journal · 2024Article
- Medication delivery errors in outpatients with percutaneous endoscopic gastrostomy: effect on tube feeding replacement.Scientific reports · 2023Article
- Inappropriate prescribing of proton pump inhibitors (PPI) in patients > 65 years at a level 2 Irish hospital.Irish journal of medical science · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProton pump inhibitors (PPI) are widely used among general practitioners (GP) and hospital doctors alike as a first-line agent for the management of various approved conditions. However, PPIs do have an established side-effect profile that can be over looked when prescribing these agents outside of their Food Drug Administration (FDA) indications.
aimsThe aim of this audit is to establish that PPIs are often prescribed without any clear documented indication as to why, particularly in the elderly population, despite multiple previous studies conducted which showed an over-use of these medicines.
methodsWe conducted a retrospective observational study of the patients admitted to an acute hospital in Ireland in February 2018. A cohort of patient charts were pulled from medical records and reviewed. Medical notes, GP letters, discharge summaries and prescriptions were reviewed in order to establish the primary indication for PPI prescription.
resultsOne hundred seventy-four (n = 174) inpatient records were randomly assessed during the audit. Of these patients, 85 of them were taking PPIs regularly. 54.7% (n = 46) were prescribed a PPI without any documented indication. 46.4% (n = 39) of these patients were > 75 years of age. 54.7% (n = 46) of patients were prescribed esomeprazole. The commonest indication for prescribing PPIs was to reduce the risk of gastric ulceration associated with NSAID use, which was 68.4% (n = 26) of those who were prescribed a PPI in accordance with guidelines.
conclusionIrrational prescribing of PPIs continues both in hospital and in general practise. It is imperative that the side-effects of these medicines are weighed against the benefit and cost effectiveness, especially in the elderly population where polypharmacy remains a substantial concern.
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