ArticleVirchows Archiv : an international journal of pathology2018
Local vs. systemic pulmonary amyloidosis-impact on diagnostics and clinical management.
Article in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Clinical spectrum of Transthyretin amyloidogenic mutations among diverse population origins.Human genomics · 2024Pooled it
- Pulmonary Amyloidosis Diagnosed by Transbronchial Lung Biopsy: A Three-Case Series With Diverse Radiological Manifestations.Respirology case reports · 2026Article
- Morphological Diversity and Diagnostic Evaluation of Thoracic Amyloidosis: Insights From a Tertiary Referral Center in Vietnam.Pulmonary medicine · 2026Article
- Diffuse cystic lung diseases-a primer for radiologists.BJR open · 2026Review
- A rare presentation of pulmonary transthyretin amyloidosis.Respiratory medicine case reports · 2025Article
- Amyloidosis in Childhood: A Review of Clinical Features and Comparison with Adult Forms.Journal of clinical medicine · 2024Review
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- Article
- Imaging in pleural amyloidosis: A diagnostic challenge.Respirology case reports · 2024Article
- Nodular pulmonary amyloidosis diagnosed by ultrasound-guided percutaneous needle biopsy.Respiratory medicine case reports · 2024Article
- Noninvasive Diagnostics of Renal Amyloidosis: Current State and Perspectives.International journal of molecular sciences · 2022Review
- Multidisciplinary supportive care in systemic light chain amyloidosis.Blood research · 2022Review
- Local Insulin-Derived Amyloidosis Model Confronted with Silymarin: Histological Insights and Gene Expression of MMP, TNF-α, and IL-6.International journal of molecular sciences · 2022Article
- A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications.The Biochemical journal · 2022Review
- Pulmonary amyloidosis and multiple myeloma mimicking lymphoma in a patient with Sjogren's syndrome: A case report.World journal of clinical cases · 2022Article
- Supportive Care and Symptom Management for Patients With Immunoglobulin Light Chain (AL) Amyloidosis.Frontiers in oncology · 2022Review
- Emerald Sign for Diagnosing Tracheobronchial Amyloidosis.Internal medicine (Tokyo, Japan) · 2021Article
- Pulmonary amyloidosis mimicking interstitial lung disease and malignancy - A case series with a review of a pulmonary patterns.Respiratory medicine case reports · 2021Article
- Case Report: Management of Primary Tracheobronchial Light Chain Amyloidosis in a Patient With Biclonal Gammopathy Using a Systemic Bortezomib-Based Regimen.Frontiers in medicine · 2021Article
- Amyloidosis of the respiratory system: 16 patients with amyloidosis initially diagnosedERJ open research · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoglobulin-derived light-chain (AL) amyloidosis of lungs and bronchi can appear as a systemic and a local form. While systemic AL amyloidosis may need haemato-oncological care, the localised form can be treated restrained. We re-evaluated 207 specimens of lungs and bronchi sent in for amyloid diagnostics. Amyloid was diagnosed by polarization microscopy using Congo red-stained tissue specimens and classified immunohistochemically. Histoanatomical amyloid distribution patterns were documented as well as additional histological findings. For 118 patients with AL amyloidosis, we retrieved clinical data. CT scan results were available from 59 patients. AL amyloidosis was the most common type (183 cases). ALλ was found in 141 and of ALκ in 27 cases. Fifteen cases were AL amyloid not otherwise specified. Twenty cases harboured transthyretin and three serum amyloid A derived amyloid. By correlation of histoanatomy, radiological and clinical data, amyloid was rarely in the initial differential diagnosis. Local AL amyloidosis often presented with a nodular pattern on CT scan and showed a significantly better disease-specific 10-year survival compared with systemic AL amyloidosis (96.0 vs. 51.9%). Localised and systemic pulmonary and bronchial AL amyloidosis are having a completely different prognosis. While CT scan might be indicative, histological and clinical assessment are mandatory to reach a proper diagnosis and guide patient care.
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