ArticlePsychopharmacology2018
Investigating dopamine and glucocorticoid systems as underlying mechanisms of anhedonia.
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Research agenda to advance anhedonia assessment, understanding and treatment: an ECNP-GALENOS expert meeting report.BMJ mental health · 2026Review
- Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings.Nature. Mental health · 2026Article
- Reverse Translation.Perspectives on behavior science · 2026Article
- The development of translational tasks for preclinical psychedelic research in psychiatry.Journal of psychopharmacology (Oxford, England) · 2026Review
- Neonatal striatal volume is associated with infant anhedonia.Journal of affective disorders · 2026Article
- Beta and High Gamma Oscillations in the Cortico-striatal Network Reflect Reward Certainty on a Probabilistic Reversal Learning Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Environmental determinants of ketamine's prohedonic and antianhedonic efficacy: Persistence of enhanced reward responsiveness is modulated by chronic stress.The Journal of pharmacology and experimental therapeutics · 2025Article
- Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix.Journal of neurochemistry · 2025Review
- Effects of GABA, Sex, and Stress on Reward Learning in Current and Remitted Major Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Validation of a touchscreen probabilistic reward task for mice: A reverse-translated assay with cross-species continuity.Cognitive, affective & behavioral neuroscience · 2024Article
- Characterization of GABAergic marker expression in prefrontal cortex in dexamethasone induced depression/anxiety model.Frontiers in endocrinology · 2024Article
- Review
- Electrophysiological signatures of reward learning in the rodent touchscreen-based Probabilistic Reward Task.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Effects of dopamine modulation on chronic stress-induced deficits in reward learning.Cognitive, affective & behavioral neuroscience · 2022Article
- Toward a Better Understanding of the Mechanisms and Pathophysiology of Anhedonia: Are We Ready for Translation?The American journal of psychiatry · 2022Review
- Effects of stress on endophenotypes of suicide across species: A role for ketamine in risk mitigation.Neurobiology of stress · 2022Review
- A cross-species assay demonstrates that reward responsiveness is enduringly impacted by adverse, unpredictable early-life experiences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Probabilistic Reinforcement Learning and Anhedonia.Current topics in behavioral neurosciences · 2022Article
- Toward a Quantification of Anhedonia: Unified Matching Law and Signal Detection for Clinical Assessment and Drug Development.Perspectives on behavior science · 2021Article
- Anhedonia difference between major depressive disorder and bipolar disorder II.BMC psychiatry · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
rationaleAnhedonia, a deficit in reward processing, is an endophenotype of several neuropsychiatric conditions. Despite its prevalence and debilitating effects, treatments for anhedonia are lacking, primarily because its underlying mechanisms are poorly understood. Dopamine (DA) has been implicated in anhedonia through its role in reward-related learning; glucocorticoid systems may also be involved in that anhedonia is often preceded by chronic stress.
objectiveThis study investigated DA and glucocorticoid systems in anhedonia using a rat version of the probabilistic reward task (PRT).
methodsAdult male Wistar rats were trained on the PRT and then tested following: (1) activation or inhibition of DA activity induced by amphetamine (AMPH) or pramipexole (PRAMI) injections, (2) chronic mild stress (CMS), or (3) glucocorticoid system activation (dexamethasone (DEX)) or inhibition (mifepristone (MIFE)).
resultsAMPH increased and PRAMI decreased response bias, pointing to enhanced and diminished reward responsiveness with DA agonism and antagonism, respectively. CMS reduced response bias but only in a subpopulation of rats. DEX also decreased response bias, suggesting that glucocorticoid processes contribute to anhedonia, although glucocorticoid inhibition (MIFE) had no effect. None of the manipulations altered the ability to detect and respond to reward-paired stimuli.
conclusionsThese results confirm a role of DA in anhedonia and elucidate the contribution of the glucocorticoid system to this effect. In addition, chronic stress may interfere with normal DA functioning, leading to impaired reward-related learning in some animals. These findings may direct future treatment of anhedonia by targeting DA and glucocorticoid systems, as well as a possible interaction between the two.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.