ReviewIntensive care medicine2018
Time-limited trial of intensive care treatment: an overview of current literature.
Review in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07035951 (The VIP-3), which is not on this map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The VIP-3 (Very Old Intensive Care Patients) Study: Decision-making in the Older Intensive Care Unit (ICU) Patient: How Are Family Meetings Implemented Across Diverse Cultures in Europe?
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- European Society of Intensive Care Medicine guidelines on end of life and palliative care in the intensive care unit.Intensive care medicine · 2024Guideline
- Managing ICU surge during the COVID-19 crisis: rapid guidelines.Intensive care medicine · 2020Guideline
- Recognise, respond, reflect: A value-based framework for rapid response teams.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Admission to intensive care: a matter of shared decision-making in the very old?European geriatric medicine · 2026Review
- Time-limited trials for acute dialysis decision-making for critically ill older patients: rationale, communication strategies, and future research.Current opinion in nephrology and hypertension · 2026Review
- Unravelling the complexities of end-of-life critical care interventions: what drives medico-legal complaints to physicians?BMC health services research · 2026Article
- Survival and quality-adjusted life years in critically ill cancer patients: analysis on the fifth day of intensive care unit stay.Critical care science · 2026Article
- Characterizing ICU-like profiles of very old patients hospitalized in medical intermediate care units in France: A clustering analysis of a nationwide population-based study.Annals of intensive care · 2026Article
- Life-Supporting Treatment Limitations in Patients Who Die Within 48 Hours After ICU Admission: A French, Multicenter, Observational, Exploratory Study.Critical care explorations · 2025Observational
- Accuracy of Intensivist Prognostications of Deterioration within the Intensive Care Unit and Development of Persistent Critical Illness: A Prospective Cohort Study.Annals of the American Thoracic Society · 2025Article
- Timing of onset of persistent critical illness in Japan: a nationwide registry study.The Lancet regional health. Western Pacific · 2025Article
- Observational
- Liberation and discharge status of older patients after invasive mechanical ventilation: a retrospective cohort study.BMC geriatrics · 2025Article
- Targeted antineoplastic therapy in critically ill cancer patients: a multicenter analysis of the iCHOP registry.Annals of hematology · 2025Article
- Time-Limited Trials in Intensive Care Medicine: A Tool for Avoiding Inappropriate Treatment.Deutsches Arzteblatt international · 2025Review
- Outcomes in immunocompromised patients with acute hypoxemic respiratory failure treated by high-flow nasal oxygen.Intensive care medicine · 2025Article
- Consideration of advance directives by emergency physicians in patients with cardiac arrest: a clinical vignettes-based qualitative study.International journal of emergency medicine · 2024Article
- Characterizing the Use of Time-Limited Trials in Patients With Acute Respiratory Failure: A Prospective, Single-Center Observational Study.Critical care explorations · 2024Observational
- The truism of 'life limiting illness' in ICU.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- Critical care beyond organ support: the importance of geriatric rehabilitation.Annals of intensive care · 2024Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In critically ill patients, it is frequently challenging to identify who will benefit from admission to the intensive care unit and life-sustaining interventions when the chances of a meaningful outcome are unclear. In addition, the acute illness not only affects the patients but also family members or surrogates who often are overwhelmed and unable to make thoughtful decisions. In these circumstances, a time-limited trial (TLT) of intensive care treatment can be helpful. A TLT is an agreement to initiate all necessary treatments or treatments with clearly delineated limitations for a certain period of time to gain a more realistic understanding of the patient's chances of a meaningful recovery or to ascertain the patient's wishes and values. In this article, we discuss current research on different aspects of TLTs in the intensive care unit. We propose how and when to use TLTs, discuss how much time should be taken for a TLT, give an overview of the potential impact of TLTs on healthcare resources, describe ethical challenges concerning TLTs, and discuss how to evaluate a TLT.
Indexed as
Identifiers
30136140What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.