Evidence map›Paper›PMID 30135950›Full record

ArticleIBRO reports2018

Effects of an early life experience on rat brain cannabinoid receptors in adolescence and adulthood.

Chara Vangopoulou, Maria T Bourmpoula, Christina Koupourtidou, Panagiotis Giompres, Antonios Stamatakis, Elias D Kouvelas, Ada Mitsacos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IBRO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Early Consumption of Cannabinoids: From Adult Neurogenesis to Behavior.International journal of molecular sciences · 2021
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chara VangopoulouLaboratory of Physiology, Medical School, University of Patras, 26500, Patras, Greece.
Maria T BourmpoulaLaboratory of Physiology, Medical School, University of Patras, 26500, Patras, Greece.
Christina KoupourtidouLaboratory of Physiology, Medical School, University of Patras, 26500, Patras, Greece.
Panagiotis GiompresLaboratory of Human and Animal Physiology, Department of Biology, University of Patras, 265040, Patras, Greece.
Antonios StamatakisLaboratory of Biology-Biochemistry, Faculty of Nursing, University of Athens, 11527, Athens, Greece.
Elias D KouvelasLaboratory of Physiology, Medical School, University of Patras, 26500, Patras, Greece.
Ada MitsacosLaboratory of Physiology, Medical School, University of Patras, 26500, Patras, Greece.
University of Patras · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal handling is an experimental model of early life experience associated with resilience in later life challenges, altering the ability of animals to respond to stress. The endocannabinoid system of the brain modulates the neuroendocrine and behavioral effects of stress, while this system is also capable of being modulated by stress exposure itself. The present study has addressed the question of whether neonatal handling in rats could affect cannabinoid receptors, in an age- and sex-dependent manner, using

Indexed as

2-AG, 2-arachidonoylglycerolAdolescenceANOVA, analysis of varianceBLA, basolateral nucleus of amygdalaBSA, bovine serum albuminCA1, dorsal field 1 of Ammon’s hornCA3, dorsal field 3 of Ammon’s hornCB1, cannabinoid receptor 1CB1 cannabinoid receptorsCeA, central amygdaloid nucleusCg1, anterior cingulate cortexCPu-DL, dorsolateral striatumCPu-VM, ventromedial striatumDG, dentate gyruseCB, endocannabinoidFemale rat brainGrDG, dentate gyrus granule cell layerGR, glucocorticoid receptorsHPA, hypothalamic-pituitary-adrenalIL, infralimbic cortexLTD, long-term depressionMale rat brainMaternal separationMoDG, dentate gyrus molecular layerMO, medial orbital cortexmPFC, medial prefrontal cortexNAc, nucleus accumbensNeonatal handlingNS, not significantPFC, prefrontal cortexPND, postnatal dayPrL, prelimbic cortexROD, relative optical densityRT, room temperature

Identifiers

PMID30135950
PMCPMC6095101
OpenAlexW2805268326

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.