ArticleIBRO reports2017
Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice.
Article in IBRO reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Delta-fast ripple coupling suppression: designing a brain-mimetic stimulation paradigm for seizure abolishment.Frontiers in neuroscience · 2025Article
- Article
- Age-Dependent Phenomena of 6-Hz Corneal Kindling Model in Mice.Molecular neurobiology · 2024Article
- Age-Dependent Reduction in the Expression Levels of Genes Involved in Progressive Myoclonus Epilepsy Correlates with Increased Neuroinflammation and Seizure Susceptibility in Mouse Models.Molecular neurobiology · 2022Article
- Network activity changes in the pathophysiology of Alzheimer's disease: the role of aging and early entorhinal cortex dysfunction.Metabolic brain disease · 2022Review
- Can Old Animals Reveal New Targets? The Aging and Degenerating Brain as a New Precision Medicine Opportunity for Epilepsy.Frontiers in neurology · 2022Review
- Convulsive behaviors of spontaneous recurrent seizures in a mouse model of extended hippocampal kindling.Frontiers in behavioral neuroscience · 2022Article
- Zona incerta subpopulations differentially encode and modulate anxiety.Science advances · 2021Article
- Clustering of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling.Frontiers in neurology · 2021Article
- Electrographic Features of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling.Cerebral cortex communications · 2021Article
- Temperature elevation in epileptogenic foci exacerbates epileptic discharge through TRPV4 activation.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Deletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice.Scientific reports · 2019Article
- Impaired Spatial Learning and Memory in Middle-Aged Mice with Kindling-Induced Spontaneous Recurrent Seizures.Frontiers in pharmacology · 2019Article
- Alteration of Extracellular Matrix Molecules and Perineuronal Nets in the Hippocampus of Pentylenetetrazol-Kindled Mice.Neural plasticity · 2019Article
- Effects of Antiepileptic Drugs on Spontaneous Recurrent Seizures in a Novel Model of Extended Hippocampal Kindling in Mice.Frontiers in pharmacology · 2018Article
- Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of seizures increases with old age. Stroke, dementia and brain tumors are recognized risk factors for new-onset seizures in the aging populations and the incidence of these conditions also increased with age. Whether aging is associated with higher seizure susceptibility in the absence of the above pathologies remains unclear. We used classic kindling to explore this issue as the kindling model is highly reproducible and allows close monitoring of electrographic and motor seizure activities in individual animals. We kindled male young and aging mice (C57BL/6 strain, 2-3 and 18-22 months of age) via daily hippocampal CA3 stimulation and monitored seizure activity via video and electroencephalographic recordings. The aging mice needed fewer stimuli to evoke stage-5 motor seizures and exhibited longer hippocampal afterdischarges and more frequent hippocampal spikes relative to the young mice, but afterdischarge thresholds and cumulative afterdischarge durations to stage 5 motor seizures were not different between the two age groups. While hippocampal injury and structural alterations at cellular and micro-circuitry levels remain to be examined in the kindled mice, our present observations suggest that susceptibility to hippocampal CA3 kindling seizures is increased with aging in male C57 black mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.