ReviewRestorative dentistry & endodontics2018
Triple antibiotic paste: momentous roles and applications in endodontics: a review.
Review in Restorative dentistry & endodontics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Materials for pulpotomy in immature permanent teeth: a systematic review and meta-analysis.BMC oral health · 2019Pooled it
- Pediococcus acidilactici JUFB as a probiotic antibiofilm adjunct against Enterococcus faecalis in persistent endodontic infections.Antonie van Leeuwenhoek · 2026Article
- Comparative antimicrobial efficacy of three intracanal medicaments in an in vitro Enterococcus faecalis root canal infection model.BMC oral health · 2026Article
- Chihuahuan Propolis as a Non-Antibiotic Intracanal Agent AgainstMicroorganisms · 2026Article
- Regenerative Endodontic Treatment in Permanent Incisors: Two Case Reports with 6 Years of Follow-Up.Children (Basel, Switzerland) · 2026Article
- Comparison of the Antimicrobial Properties of Nanoemulsions Made from Phytosphingosine and Chitosan with a Triple Antibiotic Paste AgainstInternational journal of nanomedicine · 2026Article
- Antibacterial Effect of Cannabinoids on Bacteria Associated with Persistent Endodontic Infections.International journal of molecular sciences · 2025Article
- Effect of Chitosan and bioactive glass nanomaterials as intracanal medicaments on TGF-β1 release from intraradicular dentin.BMC oral health · 2025Article
- Clinical and radiographic success of lesion sterilization and tissue repair in primary teeth: a systematic review and meta-analysis.The Saudi dental journal · 2025Article
- In Vitro Effectiveness of Endodontic Triple Antibiotic Paste Associated With Daptomycin.Cureus · 2025Article
- Comparative Evaluation of Calcium Hydroxide, Triple Antibiotic Paste, and Calcium Hydroxide with 2% Chlorhexidine as Intracanal Medicaments in Reducing Interappointment Pain during Endodontic Treatment: AnInternational journal of clinical pediatric dentistry · 2025Article
- Microbial Dynamics in Endodontic Pathology-From Bacterial Infection to Therapeutic Interventions-A Narrative Review.Pathogens (Basel, Switzerland) · 2024Review
- Triple Antibiotic Paste: A Game Changer in Endodontics.Journal of pharmacy & bioallied sciences · 2024Review
- Article
- Article
- Comparison of Antibacterial Efficacy of Triple Antibiotic-Loaded Hydrogel Versus Modified Triple Antibiotic-Loaded Hydrogel as Intracanal Medicament Against Enterococcus faecalis: An In vitro Study.European endodontic journal · 2024Article
- A Comparative Evaluation of Herbal Extracts and Triple Antibiotic Paste as Intracanal Medicament againstInternational journal of clinical pediatric dentistry · 2024Article
- Article
- Article
- Regenerative Endodontic Treatment in Dentinogenesis Imperfecta-Induced Apical Periodontitis.Case reports in dentistry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the latest findings and notions regarding 'triple antibiotic paste' (TAP) and its applications in dentistry, particularly endodontics. TAP is a combination of 3 antibiotics, ciprofloxacin, metronidazole, and minocycline. Despite the problems and pitfalls research pertaining to this paste has unveiled, it has been vastly used in endodontic treatments. The paste's applications vary, from vital pulp therapy to the recently introduced regeneration and revascularisation protocol. Studies have shown that the paste can eliminate the root canal microorganisms and prepare an appropriate matrix for further treatments. This combination is able to remove diverse groups of obligate and facultative gram-positive and gram-negative bacteria, providing an environment for healing. In regeneration protocol cases, this allows the development, disinfection, and possible sterilization of the root canal system, so that new tissue can infiltrate and grow into the radicular area. Moreover, TAP is capable of creating a discipline in which other wanted and needed treatments can be successfully performed. In conclusion, TAP, as an antibacterial intracanal medication, has diverse uses. Nevertheless, despite its positive effects, the paste has shown drawbacks. Further research concerning the combined paste and other intracanal medications to control microbiota is a must.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.