Evidence map›Paper›PMID 30135719›Full record

ReviewF1000Research2018

Recent advances in the understanding and treatment of acute myeloid leukemia.

Justin Watts, Stephen Nimer

Abstract readReview
In one paragraph

Review in F1000Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Toward Optimizing the Impact of Digital Pathology and Augmented Intelligence on Issues of Diagnosis, Grading, Staging, and Classification.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The Anti-Leukemic Activity of Natural Compounds.Molecules (Basel, Switzerland) · 2021
    Review
  15. Garcinielliptone G fromMolecules (Basel, Switzerland) · 2021
    Article
  16. Article
  17. Article
  18. CTSB Knockdown Inhibits Proliferation and Tumorigenesis in HL-60 Cells.International journal of medical sciences · 2021
    Observational
  19. Review
  20. The Role ofCancers · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Justin WattsSylvester Comprehensive Cancer Center and Miller School of Medicine, University of Miami, Miami, Florida, USA.ORCID 0000-0001-5213-5482
Stephen NimerSylvester Comprehensive Cancer Center and Miller School of Medicine, University of Miami, Miami, Florida, USA.

Funding

Targeting p300 and lysine acetylation in AMLR01CA166835 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2012 to 2026
$4.6M
Miami Clinical and Translational Science InstituteKL2TR000461 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SACCO, RALPH L. · 2012 to 2016
$2.1M
Unlocking the Therapeutic Potential of Retinoic Acid in Acute Myeloid LeukemiaR21CA202488 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WATTS, JUSTIN M · 2016 to 2017
$367k
NCATS NIH HHS KL2 TR000461NCI NIH HHS R01 CA166835NCI NIH HHS R21 CA202488
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease that has a poor prognosis. Recent advances in genomics and molecular biology have led to a greatly improved understanding of the disease. Until 2017, there had been no new drugs approved for AML in decades. Here, we review novel drug targets in AML with a focus on epigenetic-targeted therapies in pre-clinical and clinical development as well as the recent new drug approvals.

Indexed as

Drug ApprovalEpigenesis, GeneticHumansLeukemia, Myeloid, AcuteMolecular Targeted Therapyacute myeloid leukemia (AML); genomics; epigenetics; targeted therapies; drug development

Identifiers

PMID30135719
PMCPMC6081972

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.