Evidence map›Paper›PMID 30135717›Full record

ReviewF1000Research2018

Recent advances in prostate cancer research: large-scale genomic analyses reveal novel driver mutations and DNA repair defects.

Sander Frank, Peter Nelson, Valeri Vasioukhin

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in F1000Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05156450 (Phase Ib/II Clinical Study of TQB3616 Capsules in Combination With Abiraterone Acetate Plus Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer), which is not on this map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05156450 phase2unknown statusnot on this mapstarted 2022, after this paper: background citation

Phase Ib/II Clinical Study of TQB3616 Capsules in Combination With Abiraterone Acetate Plus Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer

TypeinterventionalSponsorWest China HospitalRan2022 to 2024Enrolled30ConditionsProstatic Neoplasms, Castration-Resistant, Drug Therapy, CombinationArmsTQB3616 Capsules Combined With Abiraterone Acetate Plus Prednisone
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sander FrankDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Peter NelsonDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Valeri VasioukhinDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.ORCID 0000-0002-6730-0281
University of Washington · USFred Hutch Cancer Center · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
TRANSCRIPTOME AND PROTEOME STRATIFICATION OF PROSTATE ADENOCARCINOMA PHENOTYPESP50CA097186 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETER S NELSON · 2002 to 2026
$58.1M
The Hippo Pathway in Prostate Gland Homeostasis and Prostate CancerR01CA176844 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI VASIOUKHIN, VALERI · 2013 to 2017
$1.8M
NCI NIH HHS P30 CA015704NCI NIH HHS P50 CA097186NCI NIH HHS R01 CA176844
6 · The paper itself

Abstract

Prostate cancer (PCa) is a disease of mutated and misregulated genes. However, primary prostate tumors have relatively few mutations, and only three genes (

Indexed as

DNA RepairGenomicsMutationAnimalsHumansMaleMolecular Targeted TherapyNeoplasm MetastasisProstatic Neoplasms3D cultureBRCAimmunotherapyPARPprostate cancersequencingxenograft

Identifiers

PMID30135717
PMCPMC6073096
OpenAlexW2887136529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.