ArticleFrontiers in immunology2018
Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia.
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Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 2 of them syntheses that pooled it.
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108citing papers in PubMed, 2 pooled it
16.6field-weighted citation impact, top 1% of its field
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Who cites it
108 citing papers in PubMed, 2 syntheses or guidelines pooled it, 192 citations in OpenAlex.
- SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis.American journal of obstetrics and gynecology · 2022Pooled it
- Current approaches and developments in transcript profiling of the human placenta.Human reproduction update · 2020Pooled it
- Trial
- Multi-Omics Reveals Early Pregnancy Placental Dysfunction Associated With Preterm and Term Preeclampsia.MedComm · 2026Article
- PCYT1B-Targeting miRNAs as Potential Biomarkers for Placental Diseases.International journal of molecular sciences · 2026Article
- Integrated multi-omics profiling reveals the potential role of maternal systemic immune dysregulation driven by monocyte/macrophage in preeclampsia.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Identifying biomarkers of the serum proteins and metabolites associated with severe preeclampsia.BMC pregnancy and childbirth · 2026Article
- Large-Scale Proteomics Reveals New Candidate Biomarkers for Late-Onset Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2026Article
- miR-142-3p regulates RDH13 to impair trophoblast function via regulating CDH5/LFA-1/L-SELECTIN axis: a novel mechanism and diagnostic/therapeutic for pre-eclampsia.Frontiers in medicine · 2026Article
- The neuro-immune axis in preeclampsia: from the maternal-fetal interface to systemic dysregulation.Frontiers in immunology · 2026Review
- Single-cell mapping of maternal-fetal cross-talk in preeclampsia.Research square · 2025Article
- Visionary AI: Decoding Systemic Vascular Health and Hypertensive Disorders in Pregnancy Through Retinal Imaging and Artificial Intelligence.medRxiv : the preprint server for health sciences · 2025Article
- Multi-omic insights of preeclampsia and cardiovascular health outcomes.Communications medicine · 2025Review
- Maternal and placental galectins: key players in the feto-maternal symbiotic tango.Seminars in immunopathology · 2025Review
- Proteome-Based Maternal Plasma and Serum Biomarkers for Preeclampsia: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- Molecular subtyping of hypertensive disorders of pregnancy.Nature communications · 2025Article
- Association between Apolipoprotein L1 genetic variants and risk of preeclampsia and preterm birth among U.S. Black women.European journal of obstetrics & gynecology and reproductive biology: X · 2025Article
- Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface.Frontiers in immunology · 2025Article
- An interdisciplinary fetal neonatal neurology collaborative promotes integrative life-course brain health.Frontiers in neurology · 2025Review
- First-Trimester Preeclampsia-Induced Disturbance in Maternal Blood Serum Proteome: A Pilot Study.International journal of molecular sciences · 2024Article
48 more citing papers are in PubMed but not listed here.
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Authors and funding
42 authors at 15 institutions in 6 countries.
Nandor Gabor ThanPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Roberto RomeroPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Adi Laurentiu TarcaPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Katalin Adrienna KekesiLaboratory of Proteomics, Department of Physiology and Neurobiology, ELTE Eotvos Lorand University, Budapest, Hungary.
Yi XuPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Zhonghui XuPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Kata JuhaszSystems Biology of Reproduction Lendulet Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
Gaurav BhattiPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Ron Joshua LeavittZymo Research Corporation, Irvine, CA, United States.
Zsolt GelencserSystems Biology of Reproduction Lendulet Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
Janos PalhalmiSystems Biology of Reproduction Lendulet Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
Tzu Hung ChungZymo Research Corporation, Irvine, CA, United States.
Balazs Andras GyorffyLaboratory of Proteomics, Department of Physiology and Neurobiology, ELTE Eotvos Lorand University, Budapest, Hungary.
Laszlo OroszDepartment of Obstetrics and Gynaecology, University of Debrecen, Debrecen, Hungary.
Amanda DemeterSystems Biology of Reproduction Lendulet Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
Anett SzecsiSystems Biology of Reproduction Lendulet Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
Eva Hunyadi-GulyasInstitute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
Zsuzsanna DarulaInstitute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
Attila SimorLaboratory of Proteomics, Department of Physiology and Neurobiology, ELTE Eotvos Lorand University, Budapest, Hungary.
Katalin EderDepartment of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary.
Szilvia SzaboSystems Biology of Reproduction Lendulet Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
Vanessa ToppingPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Haidy El-AzzamyPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Christopher LaJeunessePerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Andrea BaloghPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Gabor SzalaiPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Susan LandCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, United States.
Olga TorokDepartment of Obstetrics and Gynaecology, University of Debrecen, Debrecen, Hungary.
Zhong DongPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Ilona KovalszkyFirst Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Andras FalusDepartment of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary.
Hamutal MeiriTeleMarpe Ltd, Tel Aviv, Israel.
Sorin DraghiciCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, United States.
Sonia S HassanPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Tinnakorn ChaiworapongsaPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Manuel KrispinZymo Research Corporation, Irvine, CA, United States.
Martin KnöflerDepartment of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
Offer ErezPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Graham J BurtonCentre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Chong Jai KimPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, United States.
Gabor JuhaszLaboratory of Proteomics, Department of Physiology and Neurobiology, ELTE Eotvos Lorand University, Budapest, Hungary.
Zoltan PappMaternity Private Department, Kutvolgyi Clinical Block, Semmelweis University, Budapest, Hungary.
United States Department of Health and Human Services · USSemmelweis University · HUEötvös Loránd University · HUNational Institutes of Health · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USHungarian Academy of Sciences · HUHUN-REN Research Centre for Natural Sciences · HUHUN-REN Szegedi Biológiai Kutatóközpont · HUInstitute of Molecular Life Sciences · HUUniversity of Debrecen · HUWayne State University · USBen-Gurion University of the Negev · ILMedical University of Vienna · ATUniversity of Cambridge · GBUniversity of Michigan–Ann Arbor · US
Funding
NICHD NIH HHS HHSN275201300006C
Abstract
Preeclampsia is a disease of the mother, fetus, and placenta, and the gaps in our understanding of the complex interactions among their respective disease pathways preclude successful treatment and prevention. The placenta has a key role in the pathogenesis of the terminal pathway characterized by exaggerated maternal systemic inflammation, generalized endothelial damage, hypertension, and proteinuria. This
Indexed as
Placenta DiseasesPre-EclampsiaAdultBiomarkersFemaleHumansPregnancyProteomicsSystems BiologyTrophoblastsBiomarkersinflammationischemialiquid biopsyomicsplacentapregnancysystems biologytrophoblast invasion
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.