Evidence map›Paper›PMID 30135646›Full record

ReviewFrontiers in cellular neuroscience2018

Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells.

Karen L Elliott, Bernd Fritzsch, Jeremy S Duncan

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Early Steps towards Hearing: Placodes and Sensory Development.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Article
  9. Review
  10. Early Deletion ofFrontiers in cell and developmental biology · 2022
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. The Kinocilia of Cochlear Hair Cells: Structures, Functions, and Diseases.Frontiers in cell and developmental biology · 2021
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Karen L ElliottDepartment of Biology, University of Iowa, Iowa City, IA, United States.
Bernd FritzschDepartment of Biology, University of Iowa, Iowa City, IA, United States.
Jeremy S DuncanDepartment of Biological Sciences, Western Michigan University, Kalamazoo, MI, United States.
University of Iowa · USWestern Michigan University · US

Funding

Three-eared frogs: A tool to dissect ear connection mechanismsR03DC015333 · NIDCD · UNIVERSITY OF IOWA · PI THOMPSON, KAREN LOUISE ELLIOTT · 2016 to 2018
$457k
Determining the Molecular Landscape Necessary for Hair Cell DifferentiationR21DC017589 · NIDCD · WESTERN MICHIGAN UNIVERSITY · PI DUNCAN, JEREMY S · 2019 to 2021
$440k
NIDCD NIH HHS R03 DC015333NIDCD NIH HHS R21 DC017589
6 · The paper itself

Abstract

We review the evolution and development of organ of Corti hair cells with a focus on their molecular differences from vestibular hair cells. Such information is needed to therapeutically guide organ of Corti hair cell development in flat epithelia and generate the correct arrangement of different hair cell types, orientation of stereocilia, and the delayed loss of the kinocilium that are all essential for hearing, while avoiding driving hair cells toward a vestibular fate. Highlighting the differences from vestibular organs and defining what is known about the regulation of these differences will help focus future research directions toward successful restoration of an organ of Corti following long-term hair cell loss.

Indexed as

hair cell kinocilium losshair cell planar cell polarityMET channel mutation effectsorgan of Corti evolutionPCP effects on sensory neurons

Identifiers

PMID30135646
PMCPMC6092489
OpenAlexW2886882309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.