Evidence map›Paper›PMID 30135641›Full record

ArticleFrontiers in molecular neuroscience2018

Mechanisms Underlying the Strong Inhibition of Muscle-Type Nicotinic Receptors by Tetracaine.

Raúl Cobo, Magdalena Nikolaeva, Armando Alberola-Die, Gregorio Fernández-Ballester, José M González-Ros, Isabel Ivorra, Andrés Morales

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Membranes · 2022
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Raúl CoboDivisión de Fisiología, Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Alicante, Spain.
Magdalena NikolaevaInstituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante, Spain.
Armando Alberola-DieDivisión de Fisiología, Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Alicante, Spain.
Gregorio Fernández-BallesterInstituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante, Spain.
José M González-RosInstituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante, Spain.
Isabel IvorraDivisión de Fisiología, Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Alicante, Spain.
Andrés MoralesDivisión de Fisiología, Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Alicante, Spain.
University of Alicante · ESUniversitat de Miguel Hernández d'Elx · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotinic acetylcholine (ACh) receptors (nAChRs) are included among the targets of a variety of local anesthetics, although the molecular mechanisms of blockade are still poorly understood. Some local anesthetics, such as lidocaine, act on nAChRs by different means through their ability to present as both charged and uncharged molecules. Thus, we explored the mechanisms of nAChR blockade by tetracaine, which at physiological pH is almost exclusively present as a positively charged local anesthetic. The nAChRs from

Indexed as

desensitizationmechanisms of blockademicrotransplanted receptorsnicotinic acetylcholine receptorstetracaineXenopus oocytes

Identifiers

PMID30135641
PMCPMC6092513
OpenAlexW2885818340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.