ArticleNature2018
Parkin and PINK1 mitigate STING-induced inflammation.
RetractedOpen access · greenAbstract readRetracted Publication
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 788 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
788citing papers in PubMed, 1 pooled it
81.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
788 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,311 citations in OpenAlex.
- Genetic association between mitochondrial DNA copy number and glioma risk: insights from causality.BMC cancer · 2024Pooled it
- AA and Parkinson's Disease.Reviews of physiology, biochemistry and pharmacology · 2027Review
- Mitophagy in cisplatin-induced kidney injury: regulatory mechanisms and therapeutic targets.Annals of medicine · 2026Review
- Remodeling of innate antiviral immunity in aging.Cell insight · 2026Review
- Role of voltage-dependent anion channel 1 in neurodegeneration: Mechanisms, implications, and therapeutic potential.Neural regeneration research · 2026Article
- cGAS-STING pathway modulation: A new hope for neural regeneration.Neural regeneration research · 2026Article
- PINK1-Parkin pathway-mediated mitophagy in sepsis: friend or foe?Molecular biology reports · 2026Review
- Yiqi Huoxue Jiedu formula protects against sepsis-associated lung injury by modulating macrophage mitophagy and mtDNA-STING signaling.Chinese medicine · 2026Article
- A combined artificial intelligence-wet lab approach identifies a pivotal role of the NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neurodegenerative diseases and immune system: From pathogenic mechanism to therapy.Neural regeneration research · 2026Article
- Mitophagy mitigates mitochondrial DNA-induced activation of cGAS-STING in autoimmune thyroiditis.Nature communications · 2026Article
- The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart.Science advances · 2026Article
- Decoding the shared genetic liability of lower respiratory tract infections via genomic structural equation modeling.BMC pulmonary medicine · 2026Article
- In vitro and in vivo rescue of dopaminergic neurons in Parkinson's disease models after Parkin gene therapy.Gene therapy · 2026Article
- Therapeutic Potential of Ginkgolic Acid C17:1 in Modulating PTEN/mtDNA/TLR9 Axis for Alleviating Chronic Pseudomonas Aeruginosa Infection in Bronchiectasis.Iranian journal of biotechnology · 2026Article
- Endosomes as central hubs of interorganellar communication and cellular homeostasis.Protein & cell · 2026Review
- Article
- Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease.Physiological reviews · 2026Review
- Mitochondria-associated endoplasmic reticulum membrane (MAM): roles in innate immunity dysregulation.Cell communication and signaling : CCS · 2026Review
- Neuronal YTHDF2 suppresses innate immune activation in Aβ pathology by promoting mScience advances · 2026Article
728 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2025-07-30Unreliable Data · Upgrade/Update of Prior Notice(s) ·
- Expression of concern · 2021-06-24Concerns/Issues about Image · Updated to Retraction ·
- Commented on by
- Commented on by
- Retracted
Authors and funding
14 authors at 5 institutions in 2 countries.
Danielle A SliterBiochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Jennifer MartinezImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Ling HaoBiochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Xi ChenTransgenics Section, Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, MD, USA.
Nuo SunCenter for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Tara D FischerBiochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Jonathon L BurmanBiochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Yan LiThe Protein/Peptide Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Zhe ZhangBiochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Derek P NarendraNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Huaibin CaiTransgenics Section, Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, MD, USA.
Max BorscheInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Christine KleinInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Richard J YouleBiochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. youler@ninds.nih.gov.
National Institutes of Health · USNational Institute of Neurological Disorders and Stroke · USUniversity of Lübeck · DENational Heart Lung and Blood Institute · USNational Institute on Aging · US
Funding
Mitochondrial stress responses in neurodegenerationZIANS003169 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NARENDRA, DEREK · 2019 to 2025
$18.3MMechanisms of AutophagyZIANS003127 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI YOULE, RICHARD JAMES · 2011 to 2025
$16.7MTargeting Protein Aggregates for Autophagosomal DegradationZIANS002859 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI YOULE, RICHARD JAMES · 2009 to 2025
$16.1MMolecular and Pathophysiological Study of Parkinson's DiseaseZIAAG000928 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2011 to 2025
$15.8MThe Function and Pathogenic Mechanisms of LRRK2/Dardarin in Parkinson's DiseaseZIAAG000944 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2009 to 2025
$10.2MCharacterization of the molecular mechanisms of LC3-associated phagocytosis and its role in disease pathogenesisZIAES103286 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MARTINEZ, JENNIFER · 2015 to 2021
$9.2MPROGRAMMED CELL DEATH IN THE NERVOUS SYSTEMZ01NS002859 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI YOULE, RICHARD JAMES · 1992 to 2008
$3.5MIntramural NIH HHS Z01 NS002859Intramural NIH HHS ZIA NS002859NIAAA NIH HHS DFG FOR2488NIEHS NIH HHS 1ZIAES10328601
Abstract
Although serum from patients with Parkinson's disease contains elevated levels of numerous pro-inflammatory cytokines including IL-6, TNF, IL-1β, and IFNγ, whether inflammation contributes to or is a consequence of neuronal loss remains unknown
Indexed as
Immunity, InnateMitophagyAlarminsAnimalsDNA, MitochondrialHumansInflammationMembrane ProteinsMiceMice, Inbred C57BLParkinson DiseasePhysical Conditioning, AnimalProtein KinasesPTEN-Induced Putative KinaseReceptor, Interferon alpha-betaSTING ProteinAlarminsDNA, MitochondrialIfnar1 protein, mouseMembrane Proteinsparkin proteinProtein KinasesPTEN-Induced Putative KinaseReceptor, Interferon alpha-betaSting1 protein, mouseSTING ProteinUbiquitin-Protein Ligases
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.