ArticleNature2018
RAP2 mediates mechanoresponses of the Hippo pathway.
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In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 234 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
234citing papers in PubMed, 1 pooled it
18.2field-weighted citation impact, top 1% of its field
What it found
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Who cites it
234 citing papers in PubMed, 1 synthesis or guideline pooled it, 372 citations in OpenAlex.
- Pooled it
- Mechano-immunomodulatory biomaterials: From immune mechanosensing to translational design.Bioactive materials · 2026Review
- Mechanical regulation of cell memory.Nature structural & molecular biology · 2026Review
- Matrix stiffness shapes early transcriptional trajectories during hepatic stellate cell activation.Hepatology international · 2026Article
- Early targeting of the YAP/TEAD-PKC-NF-κB axis alleviates post-traumatic osteoarthritis.iScience · 2026Article
- The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin-Mediated Degradation of SPTBN1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Positive TAZ-TDG feedback loop drives proneural-to-mesenchymal transition to promote glioblastoma progression.Journal of translational medicine · 2026Article
- A Synergy between Genetics and Biochemistry Unravels the Molecular Architecture of the Hippo Signaling Pathway.Cold Spring Harbor perspectives in biology · 2026Article
- Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Mechanobiology of the Hippo-YAP Signaling Network.Cold Spring Harbor perspectives in biology · 2026Article
- Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic approach for renal fibrosis.Journal of advanced research · 2026Article
- The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling.The EMBO journal · 2026Article
- Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4-VCAM1 Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- Genome-wide Association Study Identifies SNPs and Candidate Genes Associated with Abdominal Meat Weight and Meat Yield of red Swamp Crayfish Procambarus clarkii.Marine biotechnology (New York, N.Y.) · 2026Article
- A Comprehensive Review of Nuclear Mechanics: Advances, Disease Relevance, Methodologies, and AI Applications.Cell biochemistry and biophysics · 2026Review
- Mechanobiology of hippocampal neurogenesis: directing neural stem cell fate through physical cues.Frontiers in molecular neuroscience · 2026Review
- The role of extracellular matrix stiffness in regulating fibroblast behaviors and disease progression.Frontiers in immunology · 2026Review
- RAP-2-independent roles formicroPublication biology · 2026Article
- Pericytes as key mediators of microenvironmental signaling crosstalk: implications in vascular diseases and cancer.Frontiers in cell and developmental biology · 2026Review
174 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors at 7 institutions in 4 countries.
Zhipeng MengDepartment of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Yunjiang QiuLudwig Institute for Cancer Research, La Jolla, CA, USA.
Kimberly C LinDepartment of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Aditya KumarDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Jesse K PlaconeDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Cao FangDepartment of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Kuei-Chun WangDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Shicong LuDepartment of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Margaret PanDepartment of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Audrey W HongDepartment of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Toshiro MoroishiDepartment of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Min LuoDepartment of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Steven W PlouffeDepartment of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Yarui DiaoLudwig Institute for Cancer Research, La Jolla, CA, USA.
Zhen YeLudwig Institute for Cancer Research, La Jolla, CA, USA.
Hyun Woo ParkDepartment of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Xiaoqiong WangRobert J. Tomisch Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Fa-Xing YuChildren's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Shu ChienDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Cun-Yu WangDivision of Oral Biology and Medicine, School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.
Bing RenLudwig Institute for Cancer Research, La Jolla, CA, USA.
Adam J EnglerDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Kun-Liang GuanDepartment of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA. kuguan@ucsd.edu.
University of California, San Diego · USLudwig Cancer Research · USChildren's Hospital of Fudan University · CNCleveland Clinic · USKumamoto University · JPSichuan University · CNUniversity of California, Los Angeles · US
Funding
GRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5MPROTEIN PHOSPHORYLATION AND GROWTH FACTOR FUNCTIONR01GM051586 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROWN, JOAN HELLER · 1994 to 2024
$7.9MMolecular and Genetic Determinants of Invasion in HNSCCR01DE015964 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, CUN-YU · 2004 to 2019
$6.6MThe mTOR and Hippo pathway in cell growth and cancerR35CA196878 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUAN, KUN-LIANG · 2015 to 2019
$4.0MMolecular Mechanism and Therapy for Ocular MelanomaR01CA217642 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER · 2017 to 2022
$2.4M"Smart" Materials to Engineer a More Complete Stem Cell NicheDP2OD006460 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ENGLER, ADAM J · 2009 to 2009
$2.3MBiomaterial Mimicry of Dynamic Matrix Stiffening During Tumor ProgressionR01CA206880 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ENGLER, ADAM J, YANG, JING · 2016 to 2020
$1.8MPredoctoral Training in Translational Musculoskeletal ResearchT32AR060712 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIEBER, RICHARD L., SAH, ROBERT L · 2012 to 2016
$741kDeveloping Adhesome Technology as a Physical Marker of Highly Metastatic CellsR21CA217735 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ENGLER, ADAM J · 2018 to 2020
$623kFlow Regulation of YAP/TAZ in Atherogenesis and Therapeutic DevelopmentK99HL135416 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, MARK KUEI-CHUN · 2017 to 2018
$272kDevelopment of novel hiPSC-seeded, 3D printed vascular graftsF32HL126406 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI PLACONE, JESSE KENNETH · 2016 to 2017
$115kNCI NIH HHS R01 CA206880NCI NIH HHS R01 CA217642NCI NIH HHS R21 CA217735NCI NIH HHS R35 CA196878NHLBI NIH HHS F32 HL126406NHLBI NIH HHS K99 HL135416NIAMS NIH HHS T32 AR060712NIDCR NIH HHS R01 DE015964NIGMS NIH HHS R01 GM051586NIGMS NIH HHS T32 GM007752NIH HHS DP2 OD006460
Abstract
Mammalian cells are surrounded by neighbouring cells and extracellular matrix (ECM), which provide cells with structural support and mechanical cues that influence diverse biological processes
Indexed as
Signal TransductionAdaptor Proteins, Signal TransducingAnimalsCell Transformation, NeoplasticExtracellular MatrixFemaleGerminal Center KinasesGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsHEK293 CellsHippo Signaling PathwayHumansIntracellular Signaling Peptides and ProteinsMiceMice, Inbred NODMice, NudeAdaptor Proteins, Signal TransducingARHGAP29 protein, humanGerminal Center KinasesGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsIntracellular Signaling Peptides and ProteinsMAP4K4 protein, humanMINK1 protein, humanNerve Tissue ProteinsPhospholipase C gammaPhosphoproteinsProtein Serine-Threonine KinasesRAP2A protein, humanRAPGEF2 protein, humanRAPGEF6 protein, humanrap GTP-Binding ProteinsTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsWWTR1 protein, humanYAP1 protein, humanYAP-Signaling Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.