ArticleNature2018
Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Abstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed.
- Atomic, structural and molecular insights into GPCR ligand binding and signalling.Nature reviews. Molecular cell biology · 2026Review
- Targeting frizzled receptors (FZDs) for anti-tumor therapy: From orthosteric to allosteric inhibition.Acta pharmaceutica Sinica. B · 2026Review
- Targeting frizzleds with small-molecule compounds-back to square one or light at the end of the tunnel?The Journal of biological chemistry · 2026Review
- Targeting tumor-associated G-protein coupled receptors: beyond single-axis inhibition toward multidimensional regulation.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Frizzled-4 promotes bone formation in chickens via activation of the canonical Wnt signaling pathway.Poultry science · 2026Article
- A novel variant p.Y250C of FZD4 influences Norrine/β-catenin signaling pathway that associates with familial exudative vitreoretinopathy (FEVR).Scientific reports · 2026Article
- Pharmacological inhibition of frizzled 4 delays cell cycle progression and limits oral squamous cell carcinoma growth.Frontiers in cell and developmental biology · 2026Article
- Structural basis for regulation of Frizzled-4 signaling by the co-receptor Tetraspanin-12.bioRxiv : the preprint server for biology · 2025Article
- Predicted functional consequences of WNT ligand mutations in colorectal cancer.Biophysical journal · 2025Article
- A novel Frizzled 7 antibody disrupts the Wnt pathway and inhibits Wilms tumor growth.Frontiers in bioengineering and biotechnology · 2025Article
- A Putative Frizzled 7-Targeting Compound Acts as a Firefly Luciferase Inhibitor.Journal of medicinal chemistry · 2024Article
- Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation.Nature communications · 2024Article
- Structural basis of frizzled 7 activation and allosteric regulation.Nature communications · 2024Article
- Structural insights into Frizzled3 through nanobody modulators.Nature communications · 2024Article
- Frizzled receptors (FZDs) in Wnt signaling: potential therapeutic targets for human cancers.Acta pharmacologica Sinica · 2024Review
- DNMT3A-mediated DNA methylation and transcription inhibition of FZD5 suppresses lung carcinogenesis.Heliyon · 2024Article
- Identification of Novel FZD4 Mutations in Familial Exudative Vitreoretinopathy and Investigating the Pathogenic Mechanisms of FZD4 Mutations.Investigative ophthalmology & visual science · 2024Article
- A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.Cell discovery · 2024Article
- Structure, function and drug discovery of GPCR signaling.Molecular biomedicine · 2023Review
- G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.Signal transduction and targeted therapy · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Shifan YangiHuman Institute, ShanghaiTech University, Shanghai, China.
Yiran WuiHuman Institute, ShanghaiTech University, Shanghai, China.
Ting-Hai XuCenter for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, MI, USA.
Parker W de WaalCenter for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, MI, USA.
Yuanzheng HeHIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Mengchen PuiHuman Institute, ShanghaiTech University, Shanghai, China.
Yuxiang CheniHuman Institute, ShanghaiTech University, Shanghai, China.
Zachary J DeBruineCenter for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, MI, USA.
Bingjie ZhangiHuman Institute, ShanghaiTech University, Shanghai, China.
Saheem A ZaidiDepartments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA, USA.
Petr PopovDepartments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA, USA.
Yu GuoiHuman Institute, ShanghaiTech University, Shanghai, China.
Gye Won HanDepartments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA, USA.
Yang LuHIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Kelly Suino-PowellCenter for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, MI, USA.
Shaowei DongiHuman Institute, ShanghaiTech University, Shanghai, China.
Kaleeckal G HarikumarDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, USA.
Laurence J MillerDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, USA.
Vsevolod KatritchDepartments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA, USA.
H Eric XuCenter for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, MI, USA.
Wenqing ShuiiHuman Institute, ShanghaiTech University, Shanghai, China.
Raymond C StevensiHuman Institute, ShanghaiTech University, Shanghai, China.
Karsten MelcherCenter for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, MI, USA.
Suwen ZhaoiHuman Institute, ShanghaiTech University, Shanghai, China.
Fei XuiHuman Institute, ShanghaiTech University, Shanghai, China. xufei@shanghaitech.edu.cn.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frizzled receptors (FZDs) are class-F G-protein-coupled receptors (GPCRs) that function in Wnt signalling and are essential for developing and adult organisms
Indexed as
Binding SitesCrystallography, X-RayCysteineDishevelled ProteinsFrizzled ReceptorsHumansLigandsModels, MolecularMolecular Dynamics SimulationProtein DomainsWnt Signaling PathwayCysteineDishevelled ProteinsFrizzled ReceptorsFZD4 protein, humanLigands
Identifiers
PMID
30135577What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.