Evidence map›Paper›PMID 30135522›Full record

ArticleScientific reports2018

A peculiar case of Campylobacter jejuni attenuated aspartate chemosensory mutant, able to cause pathology and inflammation in avian and murine model animals.

L E Hartley-Tassell, C J Day, E A Semchenko, G Tram, L I Calderon-Gomez, Z Klipic, A M Barry, A K Lam, M A McGuckin, V Korolik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. AFrontiers in microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

L E Hartley-TassellInstitute for Glycomics, Griffith University, Gold Coast, Queensland, 4222, Australia.
C J DayInstitute for Glycomics, Griffith University, Gold Coast, Queensland, 4222, Australia.
E A SemchenkoInstitute for Glycomics, Griffith University, Gold Coast, Queensland, 4222, Australia.
G TramInstitute for Glycomics, Griffith University, Gold Coast, Queensland, 4222, Australia.
L I Calderon-GomezInstitute for Glycomics, Griffith University, Gold Coast, Queensland, 4222, Australia.
Z KlipicInstitute for Glycomics, Griffith University, Gold Coast, Queensland, 4222, Australia.
A M BarryInstitute for Glycomics, Griffith University, Gold Coast, Queensland, 4222, Australia.
A K LamSchool of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, 4222, Australia.ORCID 0000-0003-2771-564X
M A McGuckinTranslational Research Institute, Mater Research, Brisbane, Queensland, 4102, Australia.
V KorolikInstitute for Glycomics, Griffith University, Gold Coast, Queensland, 4222, Australia. v.korolik@griffith.edu.au.
Griffith University · AUTranslational Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An attenuated Campylobacter jejuni aspartate chemoreceptor ccaA mutant caused gross pathological changes despite reduced colonisation ability in animal models. In chickens, the pathological changes included connective tissue and thickening of the mesenteric fat, as well as the disintegration of the villus tips in the large intestine, whereas in mice, hepatomegaly occurred between 48-72 hours post infection and persisted for the six days of the time course. In addition, there was a significant change in the levels of IL-12p70 in mice infected with the C. jejuni ccaA mutant. CcaA isogenic mutant was hyper-invasive in cell culture and microscopic examination revealed that it had a "run" bias in its "run-and-tumble" chemotactic behaviour. The mutant cells also exhibited lower level of binding to fucosylated and higher binding to sialylated glycan structures in glycan array analysis. This study highlights the importance of investigating phenotypic changes in C. jejuni, as we have shown that specific mutants can cause pathological changes in the host, despite reduction in colonisation potential.

Indexed as

AnimalsAspartic AcidBacterial ProteinsCampylobacter InfectionsCampylobacter jejuniChemoreceptor CellsChickensDisease Models, AnimalHost-Pathogen InteractionsInflammationIntestinal MucosaMaleMiceMice, Inbred StrainsAspartic AcidBacterial Proteins

Identifiers

PMID30135522
PMCPMC6105663
OpenAlexW2886592675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.