ArticleNature communications2018
Architecture of the native major royal jelly protein 1 oligomer.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- Yellow protein co-opted to sustain obligate symbiosis in leaf beetles.Nature communications · 2026Article
- Royal jelly induces coordinated redox and energy metabolic responses in Candida guilliermondii NP-4.World journal of microbiology & biotechnology · 2026Article
- In Silico and In Vitro Screening and Mechanisms of Angiotensin I-Converting Enzyme Inhibitory Peptides from Protein Hydrolysates of Royal Jelly.Foods (Basel, Switzerland) · 2026Article
- Ectopic expression of structurally similar major royal jelly proteins reveals their distinct functions inJournal of Zhejiang University. Science. B · 2026Article
- A nutritionally complete pollen-replacing diet protects honeybee colonies during stressful commercial pollination-requirement for isofucosterol.Proceedings. Biological sciences · 2025Article
- Pharmaceutical and Therapeutic Applications of Royal Jelly for Ocular Surface Diseases: A Comprehensive Review.Journal of ophthalmic & vision research · 2025Review
- Royal Jelly: Biological Action and Health Benefits.International journal of molecular sciences · 2024Review
- Review
- Sterol and lipid metabolism in bees.Metabolomics : Official journal of the Metabolomic Society · 2023Review
- Unraveling the Role of Antimicrobial Peptides in Insects.International journal of molecular sciences · 2023Review
- Current Status of the Bioactive Properties of Royal Jelly: A Comprehensive Review with a Focus on Its Anticancer, Anti-Inflammatory, and Antioxidant Effects.Molecules (Basel, Switzerland) · 2023Review
- Decoupling the effects of nutrition, age, and behavioral caste on honey bee physiology, immunity, and colony health.Frontiers in physiology · 2023Article
- Article
- Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity.Pharmaceutics · 2022Review
- Review
- Ethanol-soluble proteins from the royal jelly of Xinjiang black bees.Protein science : a publication of the Protein Society · 2021Article
- Article
- Antibacterial Effect of Honey-Derived Exosomes Containing Antimicrobial Peptides Against Oral Streptococci.International journal of nanomedicine · 2021Article
- Structure of native glycolipoprotein filaments in honeybee royal jelly.Nature communications · 2020Article
- Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
Abstract
Honeybee caste development is nutritionally regulated by royal jelly (RJ). Major royal jelly protein 1 (MRJP1), the most abundant glycoprotein among soluble royal jelly proteins, plays pivotal roles in honeybee nutrition and larvae development, and exhibits broad pharmacological activities in humans. However, its structure has long remained unknown. Herein, we identify and report a 16-molecule architecture of native MRJP1 oligomer containing four MRJP1, four apisimin, and eight unanticipated 24-methylenecholesterol molecules at 2.65 Å resolution. MRJP1 has a unique six-bladed β-propeller fold with three disulfide bonds, and it interacts with apisimin mainly by hydrophobic interaction. Every four 24-methylenecholesterol molecules are packaged by two MRJP1 and two apisimin molecules. This assembly dimerizes to form an H-shaped MRJP1
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.