Evidence map›Paper›PMID 30135492›Full record

ArticleScientific reports2018

In vitro and in vivo evidences for innate immune stimulators lactic acid bacterial starters isolated from fermented camel dairy products.

Khaled Elbanna, Sahar El Hadad, Abdelrahaman Assaeedi, Alia Aldahlawi, Manal Khider, Alawiah Alhebshi

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

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  15. Isolation and Characterization ofBioMed research international · 2023
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  20. Probiotic and Antifungal Attributes ofFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Khaled ElbannaDeptartment of Agricultural Microbiology, Faculty of Agriculture, Fayoum University, Fayoum, Egypt. kab00@fayoum.edu.eg.
Sahar El HadadDepartment of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Abdelrahaman AssaeediDepartment of Biology, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia.
Alia AldahlawiDepartment of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Manal KhiderDepartment of Dairy Science, Faculty of Agriculture, Fayoum University, Fayoum, Egypt.
Alawiah AlhebshiDepartment of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Fayoum University · EGKing Abdulaziz University · SAUmm al-Qura University · SAVacsera (Egypt) · EG

Funding

Umm Al-Qura University 43405009
6 · The paper itself

Abstract

Probiotics are commensals with special characteristics that are essential for the development of the immune system, and may protect mucosal surfaces against pathogens. In this study, a total of 40 lactic acid bacteria (LAB) were isolated from different raw and fermented camel's milk samples collected from Saudi Arabia (Makkah area) and Egypt (Fayoum), and tested for the probiotic properties. Among them, Pro 4 and Pro 7 isolates exhibited excellent probiotic potential including bile salt (0.2-0.6%), phenol tolerance (0.2-0.4%) and salt tolerance (0.0-10%). Furthermore, both strains exhibited antimicrobial activity against wide range of food-borne pathogens and Dermatophytes with average zone inhibition of 37.5, 35.5, 34.5, 27.5, 25 and 23.5 mm for Staphylococcus aureus, Trichophyton mentagrophytes, Escherichia coli, Listeria monocytogens, Candida albicans and Salmonella typhi, respectively. Furthermore, the in vivo study indicated that these strains significantly improved the mucosal immune responses through an increase in expression of TLR2 and IFNγ mRNA in mice intestine as well as increased the synthesis of polyclonal IgG, IgM and IgA in mice blood sera. Accordingly, due to these unique probiotic properties, both selected strains could be potentially used as probiotic starter cultures for fermented dairy foods as well as functional food and health products.

Indexed as

Immunity, InnateLactobacillalesAnimalsAnti-Infective AgentsCamelusCandida albicansCultured Milk ProductsEscherichia coliFemaleImmunoglobulin IsotypesInterferon-gammaIntestinesMice, Inbred BALB CMicrobial Sensitivity TestsPhylogenyProbioticsAnti-Infective AgentsImmunoglobulin IsotypesInterferon-gammaTlr2 protein, mouseToll-Like Receptor 2

Identifiers

PMID30135492
PMCPMC6105719
OpenAlexW2886105400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.