ArticleScientific reports2018
Long-term potentiation in an innexin-based electrical synapse.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Activity induced GEM-4/Copine expression inhibits gap junctions and promotes thermosensory plasticity.bioRxiv : the preprint server for biology · 2026Article
- Learning with sparse reward in a gap junction network inspired by the insect mushroom body.PLoS computational biology · 2024Article
- Nerve Structure-Function: Unusual Structural Details and Unmasking of Sulfhydryl Groups by Electrical Stimulation or Asphyxia in Axon Membranes and Gap Junctions.International journal of molecular sciences · 2023Review
- Article
- Cell anatomy and network input explain differences within but not between leech touch cells at two different locations.Frontiers in cellular neuroscience · 2023Article
- Article
- Initial Variability and Time-Dependent Changes of Neuronal Response Features Are Cell-Type-Specific.Frontiers in cellular neuroscience · 2022Article
- Identification and classification of innexin gene transcripts in the central nervous system of the terrestrial slug Limax valentianus.PloS one · 2021Article
- NLR-1/CASPR Anchors F-Actin to Promote Gap Junction Formation.Developmental cell · 2020Article
- Effects of Exercise on Long-Term Potentiation in Neuropsychiatric Disorders.Advances in experimental medicine and biology · 2020Review
- Gap Junction Coding Innexin inFrontiers in synaptic neuroscience · 2020Article
- Article
- A Direct Comparison of Different Measures for the Strength of Electrical Synapses.Frontiers in cellular neuroscience · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrical synapses are formed by two unrelated gap junction protein families, the primordial innexins (invertebrates) or the connexins (vertebrates). Although molecularly different, innexin- and connexin-based electrical synapses are strikingly similar in their membrane topology. However, it remains unclear if this similarity extends also to more sophisticated functions such as long-term potentiation which is only known in connexin-based synapses. Here we show that this capacity is not unique to connexin-based synapses. Using a method that allowed us to quantitatively measure gap-junction conductance we provide the first and unequivocal evidence of long-term potentiation in an innexin-based electrical synapse. Our findings suggest that long-term potentiation is a property that has likely existed already in ancestral gap junctions. They therefore could provide a highly potent system to dissect shared molecular mechanisms of electrical synapse plasticity.
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