ArticleNature communications2018
Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 111 citations in OpenAlex.
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- The multilayered identity of B cell memory.Cellular & molecular immunology · 2026Review
- Modelling the Variability in Immunity Build-Up and Waning Following RNA-Based Vaccination.Viruses · 2025Article
- Mechanism for evolution of diverse autologous antibodies upon broadly neutralizing antibody therapy of people with HIV.Cell reports · 2025Article
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- Tissue-Resident T Cells That Promote Humoral Immunity: Emerging From the Shadow of T Follicular Helper Cells.Immunological reviews · 2025Review
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- EZH2 coordinates memory B-cell programming and recall responses.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- The role of fatty acid metabolism on B cells and B cell-related autoimmune diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract.Immunity · 2025Article
- Exploring CD169Vaccines · 2025Review
- Viral Infection and Dissemination Through the Lymphatic System.Microorganisms · 2025Review
- A guide to adaptive immune memory.Nature reviews. Immunology · 2024Review
- Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response.Science immunology · 2024Article
- An atlas of cells in the human tonsil.Immunity · 2024Article
- Differential response of IgM and IgG memory B cell populations to CD40L: insights of T cell - memory B cell interactions.Frontiers in immunology · 2024Article
- Memory B cells.Nature reviews. Immunology · 2024Review
- CD62L expression marks a functionally distinct subset of memory B cells.Cell reports · 2023Article
- The origins and longevity of IgE responses as indicated by serological and cellular studies in mice and humans.Allergy · 2023Review
9 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 4 institutions in 1 country.
Funding
Abstract
Vaccine-induced immunity depends on the generation of memory B cells (MBC). However, where and how MBCs are reactivated to make neutralising antibodies remain unknown. Here we show that MBCs are prepositioned in a subcapsular niche in lymph nodes where, upon reactivation by antigen, they rapidly proliferate and differentiate into antibody-secreting plasma cells in the subcapsular proliferative foci (SPF). This novel structure is enriched for signals provided by T follicular helper cells and antigen-presenting subcapsular sinus macrophages. Compared with contemporaneous secondary germinal centres, SPF have distinct single-cell molecular signature, cell migration pattern and plasma cell output. Moreover, SPF are found both in human and mouse lymph nodes, suggesting that they are conserved throughout mammalian evolution. Our data thus reveal that SPF is a seat of immunological memory that may be exploited to rapidly mobilise secondary antibody responses and improve vaccine efficacy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.