Evidence map›Paper›PMID 30135370›Full record

ArticleMaterials (Basel, Switzerland)2018

Efficacy of Proanthocyanidins from

Nijole Savickiene, Aiste Jekabsone, Lina Raudone, Asmaa S Abdelgeliel, Andrea Cochis, Lia Rimondini, Elina Makarova, Solveiga Grinberga, Osvalds Pugovics, Maija Dambrova and 3 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05015387 (Efficacy of Proanthocyanidins in Non-Surgical Periodontal Therapy), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05015387 phase2completednot on this mapstarted 2019, after this paper: background citation

Efficacy of Proanthocyanidins in Non-Surgical Periodontal Therapy: a Randomized Controlled Trial

TypeinterventionalSponsorLithuanian University of Health SciencesRan2019 to 2019Enrolled46ConditionsPeriodontitis, AdultArmsMinimally invasive non-surgical therapy, Subgingival application of collagen hydrogels with proanthocyanidins, Collection of saliva samples
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Antibacterial characteristics of black currant fruit extracts.BMC complementary medicine and therapies · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Discovery of Gingipains andFoods (Basel, Switzerland) · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Frontiers in pharmacology · 2023
    Article
  16. Review
  17. Review
  18. Proanthocyanidins fromPlants (Basel, Switzerland) · 2022
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Nijole SavickieneDepartment of Pharmacognosy, Lithuanian University of Health Sciences, Sukileliu av. 13, LT-50161 Kaunas, Lithuania. nijole.savickiene@lsmuni.lt.ORCID 0000-0001-9627-8231
Aiste JekabsoneLaboratory of Pharmaceutical Sciences, Institute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, Sukileliu av. 13, LT-50161 Kaunas, Lithuania. aiste.jekabsone@lsmuni.lt.ORCID 0000-0003-1527-6221
Lina RaudoneDepartment of Pharmacognosy, Lithuanian University of Health Sciences, Sukileliu av. 13, LT-50161 Kaunas, Lithuania. lina.raudone@lsmuni.lt.
Asmaa S AbdelgelielDepartment of Health Sciences, University Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy. asmaa.elgafari@sci.svu.edu.eg.
Andrea CochisDepartment of Health Sciences, University Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy. andrea.cochis@med.uniupo.it.
Lia RimondiniDepartment of Health Sciences, University Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy. lia.rimondini@med.uniupo.it.ORCID 0000-0002-7785-2282
Elina MakarovaLatvian Institute of Organic Synthesis, Aizkraukles str. 21, LV1006 Riga, Latvia. elina.makarova@farm.osi.lv.
Solveiga GrinbergaLatvian Institute of Organic Synthesis, Aizkraukles str. 21, LV1006 Riga, Latvia. solveiga@osi.lv.
Osvalds PugovicsLatvian Institute of Organic Synthesis, Aizkraukles str. 21, LV1006 Riga, Latvia. osvalds@osi.lv.
Maija DambrovaLatvian Institute of Organic Synthesis, Aizkraukles str. 21, LV1006 Riga, Latvia. maija.dambrova@farm.osi.lv.
Ingrida M PacauskieneClinic of Dental and Oral Pathology, LSMU Hospital, Kaunas Clinics, Medical Academy, Lithuanian University of Health Sciences, Eivenių str. 2, LT-50161 Kaunas, Lithuania. ipacauskiene@gmail.com.ORCID 0000-0001-7170-8768
Nomeda BasevičieneClinic of Dental and Oral Pathology, LSMU Hospital, Kaunas Clinics, Medical Academy, Lithuanian University of Health Sciences, Eivenių str. 2, LT-50161 Kaunas, Lithuania. bnomeda@gmail.com.
Pranas ViškelisLaboratory of Biochemistry and Technology, Institute for Horticulture, Lithuanian Research Centre for Agriculture and Forestry, Kauno str. 30, LT-54333 Babtai, Lithuania. biochem@lsdi.lt.ORCID 0000-0001-5546-0168
Latvijas Organiskās Sintēzes Institūts · LVLithuanian University of Health Sciences · LTUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITHospital of Lithuanian University of Health Sciences Kaunas Clinics · LTLithuanian Research Centre for Agriculture and Forestry · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial resistance to antibiotics and the disruption of beneficial microbiota are key problems in contemporary medicine and make the search for new, more efficient infection treatment strategies among the most important tasks in medicine. Multicomponent plant-derived preparations with mild antibacterial activity created by many simultaneous mechanisms together with anti-inflammatory, innate immune and regenerative capacity-stimulating properties are good candidates for this therapy, and proanthocyanidins are among the most promising compounds of this sort. In this study, we have isolated proanthocyanidins from

Indexed as

antioxidant activitybacteriotoxicityLC/MS/MSPelargonium sidoides root extractproanthocyanidins

Identifiers

PMID30135370
PMCPMC6164244
OpenAlexW2888342103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.