Evidence map›Paper›PMID 30135319›Full record

ArticleCirculation journal : official journal of the Japanese Circulation Society2018

Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index - The INTERLIPID Study.

Maryam Zaid, Katsuyuki Miura, Akira Okayama, Hideaki Nakagawa, Kiyomi Sakata, Shigeyuki Saitoh, Nagako Okuda, Katsushi Yoshita, Sohel R Choudhury, Beatriz Rodriguez and 9 more

Open access · diamondAbstract readMulticenter Study
In one paragraph

Article in Circulation journal : official journal of the Japanese Circulation Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Low dose thirdhand smoke exposure enhances platelet functional responses in mice.Experimental biology and medicine (Maywood, N.J.) · 2026
    Article
  4. Article
  5. Article
  6. The Lipidomic Profile Discriminates Between MASLD and MetALD.Alimentary pharmacology & therapeutics · 2025
    Article
  7. Review
  8. Article
  9. Review
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  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 5 countries.

Maryam ZaidCenter for Epidemiologic Research in Asia, Shiga University of Medical Science.
Katsuyuki MiuraCenter for Epidemiologic Research in Asia, Shiga University of Medical Science.
Akira OkayamaResearch Institute of Strategy for Prevention.
Hideaki NakagawaDepartment of Epidemiology and Public Health, Kanazawa Medical University.
Kiyomi SakataDepartment of Hygiene and Preventive Medicine, Iwate Medical University.
Shigeyuki SaitohDepartment of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine.
Nagako OkudaDepartment of Health and Nutrition, University of Human Arts and Sciences.
Katsushi YoshitaDepartment of Food and Nutrition, Osaka City University.
Sohel R ChoudhuryNational Heart Foundation Hospital and Research Institute.
Beatriz RodriguezDepartment of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii and Kuakini Medical Center.
Kamal MasakiDepartment of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii and Kuakini Medical Center.
Bradley WillcoxDepartment of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii and Kuakini Medical Center.
Naoko MiyagawaDepartment of Public Health, Shiga University of Medical Science.
Tomonori OkamuraKeio University School of Medicine.
Queenie ChanMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London.
Paul ElliottMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London.
Jeremiah StamlerDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University.
Hirotsugu UeshimaCenter for Epidemiologic Research in Asia, Shiga University of Medical Science.
INTERLIPID and INTERMAP Research Groups
Shiga University of Medical Science · JPImperial College London · GBKuakini Medical Center · USIwate Medical University · JPKanazawa Medical University · JPKeio University · JPNational Heart Foundation Hospital & Research Institute · BDOsaka City University · JPSapporo Medical University · JPUniversity of Hawaiʻi at Mānoa · USUniversity of Human Arts and Sciences · JP

Funding

INTL POPULATION STUDY ON MACRONUTRIENTS AND BP INTERMAPR01HL050490 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVIGLUS, MARTHA L, ELLIOTT, PAUL · 1995 to 2013
$7.3M
Metabolomics-Measured Urinary Metabolites, Diet & BP, 17 Population Samples: INTER01HL084228 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVIGLUS, MARTHA L, ELLIOTT, PAUL · 2007 to 2014
$4.2M
Metabolic Pathways Underlying the Contrasting Sodium-BP and DASH/OmniHeart-BP RelationshipsR01HL135486 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVIGLUS, MARTHA L, ELLIOTT, PAUL · 2017 to 2020
$2.6M
NHLBI NIH HHS R01 HL050490NHLBI NIH HHS R01 HL084228NHLBI NIH HHS R01 HL135486
6 · The paper itself

Abstract

backgroundRecently, high-density lipoprotein particles (HDL-P) have been found to be more strongly inversely associated with coronary artery disease (CAD) risk than their counterpart, HDL cholesterol (HDL-C). Given that lifestyle is among the first targets in CAD prevention, we compared the associations of HDL-P and HDL-C with selected lifestyle factors. METHODS AND 

resultsWe examined 789 Japanese participants of the INTERLIPID Study: men (n=386) and women (n=403) aged 40-59 years in 1996-1998. Participants treated for dyslipidemias were excluded. Lifestyle factors included alcohol intake, smoking amount, and body mass index (BMI). Multivariable linear regression was used for cross-sectional analyses of these factors with HDL-P, HDL-C, HDL-P size subclasses (small, medium and large) and mean HDL-P size. In men, higher alcohol intake was associated with higher HDL-P and higher HDL-C. The associations of alcohol, however, were strongest with HDL-P. A higher smoking amount tended to be associated with lower HDL-P and HDL-C. In contrast, BMI was not associated with HDL-P, but was strongly inversely associated with HDL-C. While alcohol intake favored larger mean HDL-P size, smoking and BMI favored a lipid profile with smaller HDL-P subclasses and overall smaller mean HDL-P size. Similar, but generally weaker results were observed in women.

conclusionsAlthough both HDL-P and HDL-C are parameters of HDL, they have different associations with alcohol, smoking and BMI.

Indexed as

Body Mass IndexAdultAlcohol DrinkingCholesterol, HDLCross-Sectional StudiesFemaleHumansJapanLife StyleLipoproteins, HDLMaleMiddle AgedRisk FactorsSmokingCholesterol, HDLLipoproteins, HDLAlcoholBody mass indexHigh-density lipoprotein cholesterolHigh-density lipoprotein particleSmoking

Identifiers

PMID30135319
PMCPMC6688485
OpenAlexW2888471823

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.