ArticleScience translational medicine2018
An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Open access · greenAbstract read
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Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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0cells of the map it votes in
26citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- An update on the landscape of collagen bioactive fragments.The FEBS journal · 2026Review
- Pulmonary organoid models demonstrate compositionally driven epithelial plasticity and immune polarization.iScience · 2026Article
- A lactobacilli-based inhaled live biotherapeutic product attenuates pulmonary neutrophilic inflammation.Nature communications · 2024Article
- Integrin signalling in joint development, homeostasis and osteoarthritis.Nature reviews. Rheumatology · 2024Review
- Impact of obesity on airway remodeling in asthma: pathophysiological insights and clinical implications.Frontiers in allergy · 2024Review
- Bronchial Asthma, Airway Remodeling and Lung Fibrosis as Successive Steps of One Process.International journal of molecular sciences · 2023Review
- Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis.Science signaling · 2023Article
- Extracellular matrix-induced signaling pathways in mesenchymal stem/stromal cells.Cell communication and signaling : CCS · 2023Review
- Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene AInternational journal of molecular sciences · 2023Article
- Matrix Metalloproteinase-12 Supports Pulmonary B Cell Follicle Formation and Local Antibody Responses During Asthma.American journal of respiratory and critical care medicine · 2022Article
- Highway toFrontiers in pharmacology · 2022Review
- Our evolving view of neutrophils in defining the pathology of chronic lung disease.Immunology · 2021Review
- A mechanism for matrikine regulation in acute inflammatory lung injury.JCI insight · 2021Article
- Perspectives on long pentraxin 3 and rheumatoid arthritis: several potential breakthrough points relying on study foundation of the past.International journal of medical sciences · 2021Review
- Neutrophils-From Bone Marrow to First-Line Defense of the Innate Immune System.Frontiers in immunology · 2021Review
- Animal Models Reflecting Chronic Obstructive Pulmonary Disease and Related Respiratory Disorders: Translating Pre-Clinical Data into Clinical Relevance.Journal of innate immunity · 2020Review
- Airway Remodeling in Asthma.Frontiers in medicine · 2020Review
- More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis.Frontiers in immunology · 2020Review
- Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2020Article
- Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte-dendritic cell antigen presentation.Science immunology · 2019Article
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Authors and funding
20 authors at 7 institutions in 4 countries.
Dhiren F PatelInflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0002-0967-9190
Teresa PeiróInflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Amelia ShoemarkRoyal Brompton and Harefield National Health Service (NHS) Trust, London SW3 6NP, UK.
Samia AktharInflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Simone A WalkerInflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Aleksander M GrabiecManchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester M13 9NT, UK.ORCID 0000-0001-9472-850X
Patricia L JacksonDivision of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Tracy HussellManchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester M13 9NT, UK.
Amit GaggarDivision of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Xin XuDivision of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jennifer L TrevorDivision of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-6072-6274
Jindong LiDivision of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Chad SteeleDivision of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Gael TavernierDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.ORCID 0000-0002-7325-9545
J Edwin BlalockDivision of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-5303-8123
Robert M NivenDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.ORCID 0000-0003-2249-960X
Lisa G GregoryInflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Angela SimpsonDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
Clare M LloydInflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0001-8977-6726
Robert J SnelgroveInflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK. robert.snelgrove@imperial.ac.uk.ORCID 0000-0002-9160-7929
University of Alabama at Birmingham · USLung Institute · USManchester Academic Health Science Centre · GBJagiellonian University · PLRoyal Brompton & Harefield NHS Foundation Trust · GBUniversidad Cardenal Herrera CEU · ESUniversity of Manchester · GB
Funding
Immunopathogenesis in fungal asthmaR01HL122426 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Chad Steele · 2015 to 2026
$5.1MA Novel Proteolytic System of Pulmonary InflammationR01HL102371 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAGGAR, AMIT · 2010 to 2021
$3.3MHL-A New Pathway for Neutrophil-induced Airway InflammationR01HL077783 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2006 to 2016
$3.2MBiology of innate IL-22 during lung fungal infectionR01HL136211 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEELE, CHAD · 2017 to 2024
$3.0MAcquired LTA4H Dysfunction in COPDR01HL110950 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2012 to 2015
$2.0MGenetics of Smoke-Altered LTA4H in COPDR01HL126596 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN, CASTALDI, PETER · 2015 to 2018
$1.6MPGP, A Possible Biomarker for COPD Exacerbations and or ProgressionR01HL114439 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2012 to 2015
$1.5MProlyl Endopeptidase-Mediated Matrix Remodeling and Inflammation in COPDI01BX001756 · VA · BIRMINGHAM VA MEDICAL CENTER · PI GAGGAR, AMIT · 2015 to 2018
–BLRD VA I01 BX001756Medical Research Council G1000758Medical Research Council MC_PC_13064NHLBI NIH HHS R01 HL077783NHLBI NIH HHS R01 HL102371NHLBI NIH HHS R01 HL110950NHLBI NIH HHS R01 HL114439NHLBI NIH HHS R01 HL122426NHLBI NIH HHS R01 HL126596NHLBI NIH HHS R01 HL136211Wellcome Trust 107059/Z/15/ZWellcome Trust 202865/Z/16/ZWellcome Trust 209458/Z/17/Z
Abstract
It is anticipated that bioactive fragments of the extracellular matrix (matrikines) can influence the development and progression of chronic diseases. The enzyme leukotriene A
Indexed as
Airway RemodelingAirway ResistanceAnimalsAsthmaBronchiCell CountDisease Models, AnimalEpithelial CellsEpoxide HydrolasesExtracellular MatrixHumansHypersensitivityInflammationInflammation MediatorsMice, Inbred C57BLMucusEpoxide HydrolasesInflammation Mediatorsleukotriene A4 hydrolaseOligopeptidesProlineprolyl-glycyl-proline
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.