ArticleThe Journal of biological chemistry2018
Heterogeneity of hypochlorous acid production in individual neutrophil phagosomes revealed by a rhodamine-based probe.
Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Sitagliptin Modulates Functional and Phenotypic Properties of Human Neutrophils Under Normal- and High-Glucose Conditions In Vitro.Molecules (Basel, Switzerland) · 2026Article
- Redox-dependent plasticity of oxMIF facilitates its interaction with CD74 and therapeutic antibodies.Redox biology · 2024Article
- Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase.iScience · 2023Review
- Detrimental Actions of Chlorinated Nucleosides on the Function and Viability of Insulin-Producing Cells.International journal of molecular sciences · 2023Article
- Human neutrophilsImmunological reviews · 2023Review
- Antioxidant Strategies to Modulate NETosis and the Release of Neutrophil Extracellular Traps during Chronic Inflammation.Antioxidants (Basel, Switzerland) · 2023Article
- Bi-fluorescentFrontiers in immunology · 2023Article
- Oxidation of bacillithiol during killing of Staphylococcus aureus USA300 inside neutrophil phagosomes.Journal of leukocyte biology · 2022Article
- Scylla, Charybdis, and navigating antimicrobial action in the neutrophil phagosome.Journal of leukocyte biology · 2022Article
- Maternal and umbilical cord blood polymorphonuclear leukocytes showed moderate oxidative burst at phagocytosis of Gardnerella vaginalis.BMC research notes · 2021Article
- Induction of the reactive chlorine-responsive transcription factor RclR in Escherichia coli following ingestion by neutrophils.Pathogens and disease · 2021Article
- Myeloperoxidase Modulates Hydrogen Peroxide Mediated Cellular Damage in Murine Macrophages.Antioxidants (Basel, Switzerland) · 2020Article
- An Ultrasensitive Fluorescence Assay for the Detection of Halides and Enzymatic Dehalogenation.ChemCatChem · 2020Article
- The phagocyte NOX2 NADPH oxidase in microbial killing and cell signaling.Current opinion in immunology · 2019Review
- Cell intrinsic functions of neutrophils and their manipulation by pathogens.Current opinion in immunology · 2019Review
- Exposure ofThe Journal of biological chemistry · 2019Article
- Reactive species and pathogen antioxidant networks during phagocytosis.The Journal of experimental medicine · 2019Review
- TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis.Frontiers in pharmacology · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rhodamine-based probe R19-S has been shown to react with hypochlorous acid (HOCl) to yield fluorescent R19, but not with some other oxidants including hydrogen peroxide. Here, we further examined the specificity of R19-S and used it for real-time monitoring of HOCl production in neutrophil phagosomes. We show that it also reacts rapidly with hypobromous acid, bromamines, and hypoiodous acid, indicating that R19-S responds to these reactive halogen species as well as HOCl. Hypothiocyanous acid and taurine chloramine were unreactive, however, and ammonia chloramine and dichloramine reacted only very slowly. MS analyses revealed additional products from the reaction of HOCl with R19-S, including a chlorinated species as a minor product. Of note, phagocytosis of opsonized zymosan or
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