Evidence map›Paper›PMID 30135127›Full record

ArticleJournal of virology2018

Polymorphisms in Rhesus Macaque Tetherin Are Associated with Differences in Acute Viremia in Simian Immunodeficiency Virus Δ

Sanath Kumar Janaka, Aidin Tavakoli-Tameh, William J Neidermyer, Ruth Serra-Moreno, James A Hoxie, Ronald C Desrosiers, R Paul Johnson, Jeffrey D Lifson, Steven M Wolinsky, David T Evans

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Sanath Kumar Janaka *Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Wisconsin, USA.
Aidin Tavakoli-Tameh *Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Wisconsin, USA.
William J NeidermyerDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Ruth Serra-MorenoDepartment of Biological Sciences, Texas Tech University, Lubbock, Texas, USA.
James A HoxieDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ronald C DesrosiersDepartment of Pathology, Miller School of Medicine, University of Miami, Florida, USA.ORCID https://orcid.org/0000-0001-6851-3003
R Paul JohnsonYerkes National Primate Center, Atlanta, Georgia, USA.
Jeffrey D LifsonAIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Steven M WolinskyDivision of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
David T EvansDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Wisconsin, USA dtevans2@wisc.edu.
University of Wisconsin–Madison · USHarvard University · USLeidos (United States) · USNorthwestern University · USTexas Tech University · USUniversity of Miami · USUniversity of Pennsylvania · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Sustained antibody delivery for durable suppression of immunodeficiency virus replicationR01AI121135 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI David T Evans · 2015 to 2026
$6.9M
KIR and MHC Class I Immunogenetics in SIV InfectionR37AI095098 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI David T Evans · 2019 to 2026
$5.6M
KIR and MHC Class I Immunogenetics in SIV InfectionR01AI095098 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI EVANS, DAVID T · 2012 to 2016
$2.7M
Lentiviral Resistance to TetherinR01AI098485 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI EVANS, DAVID T · 2012 to 2016
$2.2M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENIAID NIH HHS R01 AI095098NIAID NIH HHS R01 AI098485NIAID NIH HHS R01 AI121135NIAID NIH HHS R37 AI095098NIH HHS P51 OD011106
6 · The paper itself

Abstract

Tetherin (BST-2 or CD317) is an interferon-inducible transmembrane protein that inhibits virus release from infected cells. To determine the extent of sequence variation and the impact of polymorphisms in rhesus macaque tetherin on simian immunodeficiency virus (SIV) infection, tetherin alleles were sequenced from 146 rhesus macaques, including 68 animals infected with wild-type SIV

Indexed as

Amino Acid SequenceAnimalsBase SequenceBone Marrow Stromal Antigen 2Cell LineHEK293 CellsHumansMacaca mulattaPolymorphism, Single NucleotideSequence Analysis, RNASimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusViral LoadViral Regulatory and Accessory ProteinsViremiaBone Marrow Stromal Antigen 2NEF protein, SIVViral Regulatory and Accessory ProteinsBST-2HIV/AIDSpolymorphismrhesus macaqueSIVtetherin

Identifiers

PMID30135127
PMCPMC6206476
OpenAlexW2888002919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.