Evidence map›Paper›PMID 30134964›Full record

Trial reportTrials2018

Gonadotropin-releasing hormone antagonist versus progestin for the prevention of premature luteinising hormone surges in poor responders undergoing in vitro fertilisation treatment: study protocol for a randomised controlled trial.

Yun Wang, Yanping Kuang, Qiuju Chen, Renfei Cai

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yun WangDepartment of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Zhizaoju road no 639, Shanghai, People's Republic of China.
Yanping KuangDepartment of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Zhizaoju road no 639, Shanghai, People's Republic of China.
Qiuju ChenDepartment of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Zhizaoju road no 639, Shanghai, People's Republic of China. chenqj75@126.com.
Renfei CaiDepartment of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Zhizaoju road no 639, Shanghai, People's Republic of China. cairenfei070@sina.com.
Shanghai Ninth People's Hospital · CN

Funding

National Nature Science Foundation of China 81571397National Nature Science Foundation of China 81671520the Clinical Research Program of 9th People's Hospital, Shanghai Jiao Tong University School of Medicine 2016-JY04
6 · The paper itself

Abstract

backgroundProgress in vitrification techniques has allowed reproductive physicians to consider new strategies for using progestin as an alternative to a GnRH analogue to improve in vitro fertilisation (IVF). However, the role of progestin in blocking luteinising hormone (LH) surges and its potential in clinical practice are unclear, especially for poor responders. We designed a prospective randomised controlled trial (RCT) to compare the efficacy of a gonadotropin-releasing hormone (GnRH) antagonist and progestin in blocking LH surges and premature ovulation in poor responders. METHODS/

designPoor responders who meet the Bologna criteria will be randomised to one of two stimulation regimens-gonadotropin-releasing hormone (GnRH) antagonist or progestin-primed ovarian stimulation (PPOS)-using a computer-generated random number. Fresh embryos were transferred in the GnRH antagonist group and frozen embryos were transferred in the PPOS group. The primary outcome is the incidence of premature LH surges. Secondary outcomes include the number of oocytes retrieved, the number of embryos available for transfer, implantation rates and clinical pregnancy. The sample size for this trial is estimated as 340 participants, with 170 participants in each group. The data analysis will be by intention to treat. DISCUSSION: To our knowledge, this is the first RCT to examine the efficacy of administering progestin orally to block LH surges and premature ovulation compared with the GnRH antagonist protocols in poor responders undergoing IVF treatment.

trial registrationwww.chictr.org.cn . ChiCTR-IPR-17010906 . Registered on 18 March 2017.

Indexed as

Sperm Injections, IntracytoplasmicAdministration, OralAdultBiomarkersChinaClinical ProtocolsCryopreservationEmbryo ImplantationEmbryo TransferFemaleFertility Agents, FemaleGonadotropin-Releasing HormoneHumansInfertilityLuteinizing HormoneMaleBiomarkersFertility Agents, FemaleGonadotropin-Releasing HormoneLuteinizing HormoneMedroxyprogesterone AcetateMenotropinsProgesterone CongenersGnRH antagonistLH surgePoor respondersProgestin

Identifiers

PMID30134964
PMCPMC6106816
OpenAlexW2888496900

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.