Evidence map›Paper›PMID 30134914›Full record

SynthesisCell communication and signaling : CCS2018

Merkel cell polyomavirus and Langerhans cell neoplasm.

Ichiro Murakami, Noriko Wada, Junko Nakashima, Mitsuko Iguchi, Makoto Toi, Yumiko Hashida, Tomonori Higuchi, Masanori Daibata, Michiko Matsushita, Takeshi Iwasaki and 11 more

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cell communication and signaling : CCS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. A mutation in POLR3E impairs antiviral immune response and RNA polymerase III.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 2 countries.

Ichiro MurakamiDepartment of Pathology, Kochi Medical School, Kochi University, Kohasu, Okoh, Nankoku, Kochi, 783-8505, Japan. ichiro.murakami.09@gmail.com.
Noriko WadaDepartment of Pathology, Kochi University Hospital, 185-1 Kohasu, Okoh, Nankoku, Kochi, 783-8505, Japan.
Junko NakashimaDepartment of Pathology, Kochi Medical School, Kochi University, Kohasu, Okoh, Nankoku, Kochi, 783-8505, Japan.
Mitsuko IguchiDepartment of Pathology, Kochi Medical School, Kochi University, Kohasu, Okoh, Nankoku, Kochi, 783-8505, Japan.
Makoto ToiDepartment of Pathology, Kochi University Hospital, 185-1 Kohasu, Okoh, Nankoku, Kochi, 783-8505, Japan.
Yumiko HashidaDepartment of Microbiology and Infection, Kochi Medical School, Kochi University, Kohasu, Okoh, Nankoku, Kochi, 783-8505, Japan.
Tomonori HiguchiDepartment of Microbiology and Infection, Kochi Medical School, Kochi University, Kohasu, Okoh, Nankoku, Kochi, 783-8505, Japan.
Masanori DaibataDepartment of Microbiology and Infection, Kochi Medical School, Kochi University, Kohasu, Okoh, Nankoku, Kochi, 783-8505, Japan.
Michiko MatsushitaDepartment of Pathobiological Science and Technology, School of Health Science, Faculty of Medicine, Tottori University, 86 Nishi, Yonago, Tottori, 683-8503, Japan.
Takeshi IwasakiDepartment of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 812-8582, Japan.
Satoshi KuwamotoDepartment of Pathology, Tottori University Hospital, 86 Nishi, Yonago, Tottori, 683-8503, Japan.
Yasushi HorieDepartment of Pathology, Tottori University Hospital, 86 Nishi, Yonago, Tottori, 683-8503, Japan.
Keiko NagataDivision of Molecular Pathology, Faculty of Medicine, Tottori University, 86 Nishi, Yonago, Tottori, 683-8503, Japan.
Kazuhiko HayashiDivision of Molecular Pathology, Faculty of Medicine, Tottori University, 86 Nishi, Yonago, Tottori, 683-8503, Japan.
Takashi OkaDepartment of Virology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata, Kita-ku, Okayama, Okayama, 700-8558, Japan.
Tadashi YoshinoDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata, Kita-ku, Okayama, Okayama, 700-8558, Japan.
Toshihiko ImamuraDepartment of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Kyoto, 602-8566, Japan.
Akira MorimotoDepartment of Pediatrics, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
Shinsaku ImashukuDivision of Laboratory Medicine, Uji-Tokushukai Medical Center, 145 Ishibashi, Makishima, Uji, Kyoto, 611-0041, Japan.
Jean GogusevInserm U507 and U1016, Institut Cochin, 75014, Paris, France.
Francis JaubertAP-HP Hôpital Necker-Enfants Malades, University Paris Descartes (Paris 5), 75006, Paris, France.
Kōchi University · JPTottori University · JPOkayama University · JPInstitut Cochin · FRJichi Medical University · JPKyoto Prefectural University of Medicine · JPKyushu University · JPTottori University Hospital · JPUniversité Paris Cité · FR

Funding

Histiocytosis Association of America HAA grant 2009Japan LCH Study Group 2010, 2011, and 2012 research grantsJSPS KAKENHI (Grants-in-aid for Scientific Research) (C) 17K08743JSPS KAKENHI (Grants-in-aid for Scientific Research) (C) 23590426JSPS KAKENHI (Grants-in-aid for Scientific Research) (C) 26460451
6 · The paper itself

Abstract

backgroundThe relationship between various external agents such as pollen, food, and infectious agents and human sensitivity exists and is variable depending upon individual's health conditions. For example, we believe that the pathogenetic potential of the Merkel cell polyomavirus (MCPyV), the resident virus in skin, is variable and depends from the degree of individual's reactivity. MCPyV as well as Epstein-Barr virus, which are normally connected with humans under the form of subclinical infection, are thought to be involved at various degrees in several neoplastic and inflammatory diseases. In this review, we cover two types of Langerhans cell neoplasms, the Langerhans cell sarcoma (LCS) and Langerhans cell histiocytosis (LCH), represented as either neoplastic or inflammatory diseases caused by MCPyV.

methodsWe meta-analyzed both our previous analyses, composed of quantitative PCR for MCPyV-DNA, proteomics, immunohistochemistry which construct IL-17 endocrine model and interleukin-1 (IL-1) activation loop model, and other groups' data.

resultsWe have shown that there were subgroups associated with the MCPyV as a causal agent in these two different neoplasms. Comparatively, LCS, distinct from the LCH, is a neoplastic lesion (or sarcoma) without presence of inflammatory granuloma frequently observed in the elderly. LCH is a proliferative disease of Langerhans-like abnormal cells which carry mutations of genes involved in the RAS/MAPK signaling pathway. We found that MCPyV may be involved in the development of LCH.

conclusionWe hypothesized that a subgroup of LCS developed according the same mechanism involved in Merkel cell carcinoma pathogenesis. We proposed LCH developed from an inflammatory process that was sustained due to gene mutations. We hypothesized that MCPyV infection triggered an IL-1 activation loop that lies beneath the pathogenesis of LCH and propose a new triple-factor model.

Indexed as

Histiocytosis, Langerhans-CellHumansLangerhans CellsMerkel cell polyomavirusModels, BiologicalSarcomaBRAF mutationInterleukin-17Interleukin-1 loop modelITIH4Langerhans cell histiocytosisLangerhans cell neoplasmLangerhans cell sarcomaMerkel cell polyomavirusRAS/MAPK signaling pathwayTriple-factor model

Identifiers

PMID30134914
PMCPMC6103986
OpenAlexW2888324625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.