ArticleBMC pregnancy and childbirth2018
The effect of advanced maternal age on perinatal outcomes in nulliparous singleton pregnancies.
Article in BMC pregnancy and childbirth, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06528340 (Study of Pregnancies Outcomes in Advanced Maternal Age Women), which is not on this map. Cited by 83 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of Pregnancies Outcomes in Advanced Maternal Age Women
Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Do prenatal factors shape the risk for dementia?: A systematic review of the epidemiological evidence for the prenatal origins of dementia.Social psychiatry and psychiatric epidemiology · 2025Pooled it
- Prevalence, underlying causes, and determinants of maternal near miss in Ethiopia: a systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Correlation Between Placental Hormones and Placental Elasticity and the Relationship Between These Parameters and Pregnancy Outcomes.Journal of clinical ultrasound : JCU · 2026Article
- Predictors of Severe Histological Chorioamnionitis and Associated Neonatal Outcomes in Term Intrapartum Clinical Chorioamnionitis: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Policy Responses to the COVID-19 Pandemic in High-Income Countries and the Associated Maternal-Infant Health Outcomes: A Systematic Literature and Policy Review.Health science reports · 2026Review
- Experiences of Social Support Among Chinese Pregnant Women of Advanced Maternal Age: A Qualitative Study.Nursing open · 2026Article
- Trajectories of Gestational Weight Gain During Early and Mid-Pregnancy and Their Association with Hypertensive Disorders of Pregnancy.International journal of general medicine · 2026Article
- Urological outcomes and management of abnormal placental presentations: a retrospective study at a Lebanese center.Future science OA · 2025Article
- Increased vaginalmSystems · 2025Article
- Development of a machine learning model to identify the predictors of the neonatal intensive care unit admission.Scientific reports · 2025Article
- Article
- Associations of maternal age with outcomes in very low birth weight singleton infants: a retrospective study.Frontiers in pediatrics · 2025Article
- High-throughput sequencing unravels placental vascular dysfunction and oxidative stress as mechanistic drivers of advanced maternal age-associated pregnancy.Frontiers in genetics · 2025Article
- Birth outcomes of advanced maternal age pregnancies.Central European journal of public health · 2024Article
- Effects of Maternal Age on Fetus and Perinatal Outcomes in a Tertiary Care Center: An Observational Study.JNMA; journal of the Nepal Medical Association · 2024Observational
- Association between Age and Miscarriage in an Assisted Reproductive Technology Population: A 10-Year Cohort Study.Iranian journal of public health · 2024Article
- Advanced maternal age (AMA) and pregnancy: a feasible but problematic event.Archives of gynecology and obstetrics · 2024Review
- The influence of advanced maternal age on congenital malformations, short- and long-term outcomes in offspring of nulligravida: a Korean National Cohort Study over 15 years.Obstetrics & gynecology science · 2024Article
- Associations between maternal dietary intake and nutritional status with fetal growth at 14 to 26 weeks gestation: a cross- sectional study.BMC nutrition · 2024Article
- Trends and Disparities in Perinatal Opioid Use Disorder Treatment in Medicaid, 2007-2012.Medical care research and review : MCRR · 2024Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPregnancy at advanced maternal age has become more common in both developed and developing countries over the last decades. The association between adverse perinatal outcomes and advanced maternal age has been a matter of controversy in several studies. The objective of this study is to investigate the impact of advanced maternal age on perinatal and neonatal outcomes of nulliparous singleton pregnancies.
methodsRecords of patients admitted to the Department of Obstetrics and Gynecology, University of Cukurova School of Medicine, between January 2011 and July 2015 for routine mid-trimester fetal ultrasonography were retrospectively reviewed. The control (age: 18-34 years), advanced maternal age (35-39 years), and very advanced maternal age (> 40 years) groups included 471, 399, and 87 women, respectively.
resultsGestational diabetes, gestational hypertension, and cesarean delivery rates were more common in the very advanced maternal age group, with compared with the advanced maternal age and the younger age group. There were no significant differences in regarding rates of spontaneous preterm delivery before 34 weeks of gestation, prolonged rupture of membranes, large for gestational age infants, and operative vaginal delivery rates between the groups. Also, there were no significant differences regarding in APGAR scores, the rate of low birth weight infants, and neonatal morbidity rates between the groups. However, admission to the neonatal intensive care unit requirement was more common in the two advanced maternal age groups compared with the control group.
conclusionAdvanced maternal age is a risk factor for gestational diabetes mellitus, gestational hypertension, preeclampsia, small for gestational age infants, spontaneous late preterm delivery, and cesarean section, with significant potential clinical implications.
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