Evidence map›Paper›PMID 30134847›Full record

Trial reportBMC nephrology2018

Effect of plasma sodium concentration on blood pressure regulators during hemodialysis: a randomized crossover study.

Esmée M Ettema, Johanna Kuipers, Martijn van Faassen, Henk Groen, Arie M van Roon, Joop D Lefrandt, Ralf Westerhuis, Ido P Kema, Harry van Goor, Ron T Gansevoort and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03578510 (Is the Lower Incidence of Intradialytic Hypotension During Hemocontrol Dialysis in Comparison With Standard Hemodialysis Attributable to Enhanced to Higher Plasma Vasopressin Levels or to Enhanced Sympathetic Activity and/or to Less Nitric Oxide Production), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03578510 nacompletednot on this map

Is the Lower Incidence of Intradialytic Hypotension During Hemocontrol Dialysis in Comparison With Standard Hemodialysis Attributable to Enhanced to Higher Plasma Vasopressin Levels or to Enhanced Sympathetic Activity and/or to Less Nitric Oxide Production

TypeinterventionalSponsorUniversity Medical Center GroningenRan2012 to 2013Enrolled29ConditionsPatients With End Stage Renal Disease on HemodialysisArmsHemocontrol hemodialysis, Standard hemodialysis
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Esmée M EttemaDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, PO box 30, 001 9700, RB, Groningen, The Netherlands. e.m.ettema@umcg.nl.
Johanna KuipersDialysis Center Groningen, Groningen, The Netherlands.
Martijn van FaassenDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Henk GroenDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Arie M van RoonDepartment of Vascular Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Joop D LefrandtDepartment of Vascular Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ralf WesterhuisDialysis Center Groningen, Groningen, The Netherlands.
Ido P KemaDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Harry van GoorDepartment of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ron T GansevoortDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, PO box 30, 001 9700, RB, Groningen, The Netherlands.
Carlo A J M GaillardDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, PO box 30, 001 9700, RB, Groningen, The Netherlands.
Casper F M FranssenDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, PO box 30, 001 9700, RB, Groningen, The Netherlands.
University Medical Center Groningen · NLDialyse Centrum Groningen · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntradialytic hypotension is a common complication of hemodialysis. The Hemocontrol biofeedback system, improving intradialytic hemodynamic stability, is associated with an initial transient increase in plasma sodium levels. Increases in sodium could affect blood pressure regulators.

methodsWe investigated whether Hemocontrol dialysis affects vasopressin and copeptin levels, endothelial function, and sympathetic activity in twenty-nine chronic hemodialysis patients. Each patient underwent one standard hemodialysis and one Hemocontrol hemodialysis. Plasma sodium, osmolality, nitrite and nitrate (NOx), endothelin-1, angiopoietins-1 and 2, and methemoglobin as measures of endothelial function, plasma catecholamines as indices of sympathetic activity and plasma vasopressin and copeptin levels were measured six times during each modality. Blood pressure, heart rate, blood volume, and heart rate variability were repeatedly monitored. Generalized Estimating Equations was used to compare the course of the parameters during the two treatment modalities.

resultsPlasma sodium and osmolality were significantly higher during the first two hours of Hemocontrol hemodialysis. Overall, mean arterial pressure (MAP) was higher during Hemocontrol dialysis. Neither the measures of endothelial function and sympathetic activity nor copeptin levels differed between the two dialysis modalities. In contrast, plasma vasopressin levels were significantly higher during the first half of Hemocontrol dialysis. The intradialytic course of vasopressin was associated with the course of MAP.

conclusionsA transient intradialytic increase in plasma sodium did not affect indices of endothelial function or sympathetic activity compared with standard hemodialysis, but coincided with higher plasma vasopressin levels. The beneficial effect of higher intradialytic sodium levels on hemodynamic stability might be mediated by vasopressin.

trial registrationClinicalTrials.gov. Identifier: NCT03578510 . Date of registration: July 5th, 2018. Retrospectively registered.

Indexed as

AgedAged, 80 and overBiomarkersBlood PressureCross-Over StudiesFemaleHeart RateHumansMaleMiddle AgedNetherlandsNeurophysinsOsmolar ConcentrationProspective StudiesProtein PrecursorsRenal DialysisAVP protein, humanBiomarkersNeurophysinsProtein PrecursorsSodiumVasopressinsEndotheliumHemodialysisSodiumSympathetic activityVasopressin

Identifiers

PMID30134847
PMCPMC6106825
OpenAlexW2888376122

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.