Evidence map›Paper›PMID 30134810›Full record

ArticleMolecular medicine (Cambridge, Mass.)2018

Serologic features of cohorts with variable genetic risk for systemic lupus erythematosus.

Jyotsna Bhattacharya, Karalyn Pappas, Bahtiyar Toz, Cynthia Aranow, Meggan Mackay, Peter K Gregersen, Ogobara Doumbo, Abdel Kader Traore, Martin L Lesser, Maureen McMahon and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 5 countries.

Jyotsna BhattacharyaThe Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr, Manhasset, NY, 11030, USA.
Karalyn PappasDepartment of Statistical Science, Cornell University, Ithaca, NY, USA.
Bahtiyar TozDepartment of Internal Medicine, Istanbul University, Istanbul, Turkey.
Cynthia AranowThe Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr, Manhasset, NY, 11030, USA.
Meggan MackayThe Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr, Manhasset, NY, 11030, USA.
Peter K GregersenThe Feinstein Institute for Medical Research, Center for Genomics and Human Genetics, Manhasset, NY, USA.
Ogobara DoumboMalaria Research and Training Center, Bamako, Mali.
Abdel Kader TraoreDeputy of the Department of Internal Medicine, University Hospital, Bamako, Mali.
Martin L LesserThe Feinstein Institute for Medical Research, Center of Biostatistics Unit Manhasset, Manhasset, NY, USA.
Maureen McMahonUCLA David Geffen School of Medicine, Los Angeles, CA, 90095, USA.
Tammy UtsetUniversity of Chicago Medical Center, Chicago, IL, USA.
Earl SilvermanHospital for Sick Children, University of Toronto, Toronto, ON M5G, 1X8, Canada.
Deborah LevyHospital for Sick Children, University of Toronto, Toronto, ON M5G, 1X8, Canada.
William J McCuneUniversity of Michigan, Ann Arbor, MI, 48109, USA.
Meenakshi JollyRush University Medical Center, Chicago, IL, 60612, USA.
Daniel WallaceCedars Sinai Medical Center, Los Angeles, CA, 90048, USA.
Michael WeismanCedars Sinai Medical Center, Los Angeles, CA, 90048, USA.
Juanita Romero-DiazInstituto Nacional de Ciencias Medicas y Nutrician Salvador Zubiran, Mexico City, Mexico.
Betty DiamondThe Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr, Manhasset, NY, 11030, USA. bdiamond@northwell.edu.
Feinstein Institute for Medical Research · USCedars-Sinai Medical Center · USUniversity of Bamako · MLCornell University · USHospital for Sick Children · CAInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXIstanbul University · TRRush University Medical Center · USUniversity of California, Los Angeles · USUniversity of Chicago Medical Center · USUniversity of Michigan–Ann Arbor · USUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSystemic lupus erythematosus (SLE) is an autoimmune disease with genetic, hormonal, and environmental influences. In Western Europe and North America, individuals of West African descent have a 3-4 fold greater incidence of SLE than Caucasians. Paradoxically, West Africans in sub-Saharan Africa appear to have a low incidence of SLE, and some studies suggest a milder disease with less nephritis. In this study, we analyzed sera from African American female SLE patients and four other cohorts, one with SLE and others with varying degrees of risk for SLE in order to identify serologic factors that might correlate with risk of or protection against SLE.

methodsOur cohorts included West African women with previous malaria infection assumed to be protected from development of SLE, clinically unaffected sisters of SLE patients with high risk of developing SLE, healthy African American women with intermediate risk, healthy Caucasian women with low risk of developing SLE, and women with a diagnosis of SLE. We developed a lupus risk index (LRI) based on titers of IgM and IgG anti-double stranded DNA antibodies and levels of C1q.

resultsThe risk index was highest in SLE patients; second highest in unaffected sisters of SLE patients; third highest in healthy African-American women and lowest in healthy Caucasian women and malaria-exposed West African women.

conclusionThis risk index may be useful in early interventions to prevent SLE. In addition, it suggests new therapeutic approaches for the treatment of SLE.

Indexed as

Genetic Predisposition to DiseaseLupus Erythematosus, SystemicAdolescentAdultAgedAntibodies, AntinuclearBlack or African AmericanBlack PeopleComplement C1qFemaleHumansImmunoglobulin GImmunoglobulin MMalariaMiddle AgedWhite PeopleAntibodies, AntinuclearComplement C1qImmunoglobulin GImmunoglobulin M

Identifiers

PMID30134810
PMCPMC6016868
OpenAlexW2807315039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.