ArticleClinical & experimental metastasis
Host-mediated effectors of tumor invasion: role of mast cells in matrix degradation.
Article in Clinical & experimental metastasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Neuroinflammatory Mechanisms of Connective Tissue Fibrosis: Targeting Neurogenic and Mast Cell Contributions.Advances in wound care · 2015Review
- Chordoid meningioma, an uncommon variant of meningioma: a clinicopathologic study of 12 cases.Journal of neuro-oncology · 2006Article
- H-31 human breast cancer cells stimulate type I collagenase production in osteoblast-like cells and induce bone resorption.Clinical & experimental metastasis · 1995Article
- Effects of mast cell-macrophage interactions on the production of collagenolytic enzymes by metastatic tumor cells and tumor-derived and stromal fibroblasts.Clinical & experimental metastasis · 1995Article
- Mast cells in melanocytic tumours.Archives of dermatological research · 1995Article
- Distribution of gelatinase B (MMP-9) and type IV collagen in colorectal carcinoma.International journal of colorectal disease · 1994Article
- Mast-cell histamine is angiogenic through receptors for histamine1 and histamine2.International journal of experimental pathology · 1994Article
- The role of tissue inhibitor of metalloproteinase-1 in specific aspects of cancer progression and reproduction.Journal of neuro-oncology · 1994Review
- Fibroepithelial polyps of the vagina: are they old granulation tissue polyps?Journal of clinical pathology · 1992Article
- Mast cell modulation of tumour cell proliferation in rat mammary adenocarcinoma 13762NF.British journal of cancer · 1991Article
- Tumor-elicited polymorphonuclear cells, in contrast to "normal" circulating polymorphonuclear cells, stimulate invasive and metastatic potentials of rat mammary adenocarcinoma cells.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Sensitivity of locally recurrent rat mammary tumour cell lines to syngeneic polymorphonuclear cell, macrophage and natural killer cell cytolysis.British journal of cancer · 1988Article
- Differential organ tissue adhesion, invasion, and growth properties of metastatic rat mammary adenocarcinoma cells.Breast cancer research and treatment · 1988Article
- Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites.Cancer metastasis reviews · 1988Review
- Mast cells and matrix degradation at sites of tumour invasion in rat mammary adenocarcinoma.British journal of cancer · 1986Article
- Prosopagnosia.Journal of neurology, neurosurgery, and psychiatry · 1962Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of collagenolytic enzymes in tumor invasion and metastasis has been emphasized, but the source of enzyme activity has remained unclear. Degradation of stromal connective tissue is a common feature of invasive neoplasia, and host-tumor cell interactions are probably important for localized collagenolysis. We have examined the role of mast cells in malignant cell invasion using cells derived from the rat mammary adenocarcinoma 13762NF. Histologic studies have shown increased numbers of mast cells at the zone of tumor invasion. Mast cell products and conditioned medium from such cells stimulated the production of collagenolytic enzymes by stromal fibroblasts as well as certain subpopulations of tumor cells in vitro. The tumor cell response to mast cell-mediated stimulation of collagenolysis appears to be related to the metastatic potential of the tumor cell. A subpopulation of host fibroblasts derived from the invading tumor zone was also found to be more responsive to mast cell factors than normal fibroblasts, as judged by collagenase production. Thus the mast cell has the potential to induce collagenolytic activity from both host fibroblasts and tumor cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.