ArticleMetabolites2018
Night Shift Work Affects Urine Metabolite Profiles of Nurses with Early Chronotype.
Article in Metabolites, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Εndogenous metabolomic responses in circadian disrupted night shift working populations: a scoping review.Journal of the National Cancer Center · 2026Review
- Carnitine dysregulation in diabetic kidney disease: from pathogenic mechanism to precision biomarker.Journal of translational medicine · 2026Review
- Shift work, genetic risk, and incident gout: a prospective cohort study in the UK Biobank.Archives of public health = Archives belges de sante publique · 2026Article
- Predicting stress levels using physiological data: Real-time stress prediction models utilizing wearable devices.AIMS neuroscience · 2024Review
- The Effect of Night Shifts on 24-h Rhythms in the Urinary Metabolome of Police Officers on a Rotating Work Schedule.Journal of biological rhythms · 2023Article
- Metabolomic profiles in night shift workers: A cross-sectional study on hospital female nurses.Frontiers in public health · 2023Article
- GlycA, a Biomarker of Low-Grade Inflammation, Is Increased in Male Night Shift Workers.Metabolites · 2022Article
- Night work, chronotype and cortisol at awakening in female hospital employees.Scientific reports · 2022Article
- Article
- Disturbance of the Circadian System in Shift Work and Its Health Impact.Journal of biological rhythms · 2022Review
- Review
- Feeding Rhythms and the Circadian Regulation of Metabolism.Frontiers in nutrition · 2020Review
- Individual metabolomic signatures of circadian misalignment during simulated night shifts in humans.PLoS biology · 2019Article
- Ageing Investigation Using Two-Time-Point Metabolomics Data from KORA and CARLA Studies.Metabolites · 2019Article
Corrections and comments
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Authors and funding
23 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Night shift work can have a serious impact on health. Here, we assess whether and how night shift work influences the metabolite profiles, specifically with respect to different chronotype classes. We have recruited 100 women including 68 nurses working both, day shift and night shifts for up to 5 consecutive days and collected 3640 spontaneous urine samples. About 424 waking-up urine samples were measured using a targeted metabolomics approach. To account for urine dilution, we applied three methods to normalize the metabolite values: creatinine-, osmolality- and regression-based normalization. Based on linear mixed effect models, we found 31 metabolites significantly (false discovery rate <0.05) affected in nurses working in night shifts. One metabolite, acylcarnitine C10:2, was consistently identified with all three normalization methods. We further observed 11 and 4 metabolites significantly associated with night shift in early and late chronotype classes, respectively. Increased levels of medium- and long chain acylcarnitines indicate a strong impairment of the fatty acid oxidation. Our results show that night shift work influences acylcarnitines and BCAAs, particularly in nurses in the early chronotype class. Women with intermediate and late chronotypes appear to be less affected by night shift work.
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